9O5K

Cryo-EM structure of human SWELL1-PSA heterocomplex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (G, I, H)	Puromycin-sensitive aminopeptidase	polymer	884	99482.4	3	UniProt (P55786) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838)	Homo sapiens (human)	PSA,Cytosol alanyl aminopeptidase,AAP-S
2	D, E, F, G, H... (A, B, E, F, C...)	Volume-regulated anion channel subunit LRRC8A	polymer	817	95000.3	6	UniProt (Q8IWT6) Pfam (PF12534) Pfam (PF13855) Pfam (PF23598)	Homo sapiens (human)	Leucine-rich repeat-containing protein 8A,HsLRRC8A,Swelling protein 1

Sequence modifications

G, I, H: 44 - 919 (UniProt: P55786)

PDB	External Database	Details
Met 43	-	initiating methionine
Ala 531	Ser 531	conflict
Thr 920	-	expression tag
Gly 921	-	expression tag
Gly 922	-	expression tag
Leu 923	-	expression tag
Val 924	-	expression tag
Pro 925	-	expression tag
Arg 926	-	expression tag

A, B, E, F, C, D: 1 - 810 (UniProt: Q8IWT6)

PDB	External Database	Details
Thr 811	-	expression tag
Gly 812	-	expression tag
Gly 813	-	expression tag
Leu 814	-	expression tag
Val 815	-	expression tag
Pro 816	-	expression tag
Arg 817	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	868449.2
All*	Total formula weight	868449.2

*Water molecules are not included.