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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9O5K

Cryo-EM structure of human SWELL1-PSA heterocomplex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001678biological_processintracellular glucose homeostasis
A0002329biological_processpre-B cell differentiation
A0005225molecular_functionvolume-sensitive anion channel activity
A0005253molecular_functionmonoatomic anion channel activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005886cellular_componentplasma membrane
A0006820biological_processmonoatomic anion transport
A0006884biological_processcell volume homeostasis
A0006970biological_processresponse to osmotic stress
A0007283biological_processspermatogenesis
A0009986cellular_componentcell surface
A0015734biological_processtaurine transmembrane transport
A0015810biological_processaspartate transmembrane transport
A0016020cellular_componentmembrane
A0032024biological_processpositive regulation of insulin secretion
A0034214biological_processprotein hexamerization
A0034702cellular_componentmonoatomic ion channel complex
A0042802molecular_functionidentical protein binding
A0045663biological_processpositive regulation of myoblast differentiation
A0098656biological_processmonoatomic anion transmembrane transport
A0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
A0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
A1902476biological_processchloride transmembrane transport
B0001678biological_processintracellular glucose homeostasis
B0002329biological_processpre-B cell differentiation
B0005225molecular_functionvolume-sensitive anion channel activity
B0005253molecular_functionmonoatomic anion channel activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005886cellular_componentplasma membrane
B0006820biological_processmonoatomic anion transport
B0006884biological_processcell volume homeostasis
B0006970biological_processresponse to osmotic stress
B0007283biological_processspermatogenesis
B0009986cellular_componentcell surface
B0015734biological_processtaurine transmembrane transport
B0015810biological_processaspartate transmembrane transport
B0016020cellular_componentmembrane
B0032024biological_processpositive regulation of insulin secretion
B0034214biological_processprotein hexamerization
B0034702cellular_componentmonoatomic ion channel complex
B0042802molecular_functionidentical protein binding
B0045663biological_processpositive regulation of myoblast differentiation
B0098656biological_processmonoatomic anion transmembrane transport
B0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
B0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
B1902476biological_processchloride transmembrane transport
C0001678biological_processintracellular glucose homeostasis
C0002329biological_processpre-B cell differentiation
C0005225molecular_functionvolume-sensitive anion channel activity
C0005253molecular_functionmonoatomic anion channel activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005886cellular_componentplasma membrane
C0006820biological_processmonoatomic anion transport
C0006884biological_processcell volume homeostasis
C0006970biological_processresponse to osmotic stress
C0007283biological_processspermatogenesis
C0009986cellular_componentcell surface
C0015734biological_processtaurine transmembrane transport
C0015810biological_processaspartate transmembrane transport
C0016020cellular_componentmembrane
C0032024biological_processpositive regulation of insulin secretion
C0034214biological_processprotein hexamerization
C0034702cellular_componentmonoatomic ion channel complex
C0042802molecular_functionidentical protein binding
C0045663biological_processpositive regulation of myoblast differentiation
C0098656biological_processmonoatomic anion transmembrane transport
C0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
C0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
C1902476biological_processchloride transmembrane transport
D0001678biological_processintracellular glucose homeostasis
D0002329biological_processpre-B cell differentiation
D0005225molecular_functionvolume-sensitive anion channel activity
D0005253molecular_functionmonoatomic anion channel activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005765cellular_componentlysosomal membrane
D0005886cellular_componentplasma membrane
D0006820biological_processmonoatomic anion transport
D0006884biological_processcell volume homeostasis
D0006970biological_processresponse to osmotic stress
D0007283biological_processspermatogenesis
D0009986cellular_componentcell surface
D0015734biological_processtaurine transmembrane transport
D0015810biological_processaspartate transmembrane transport
D0016020cellular_componentmembrane
D0032024biological_processpositive regulation of insulin secretion
D0034214biological_processprotein hexamerization
D0034702cellular_componentmonoatomic ion channel complex
D0042802molecular_functionidentical protein binding
D0045663biological_processpositive regulation of myoblast differentiation
D0098656biological_processmonoatomic anion transmembrane transport
D0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
D0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
D1902476biological_processchloride transmembrane transport
E0001678biological_processintracellular glucose homeostasis
E0002329biological_processpre-B cell differentiation
E0005225molecular_functionvolume-sensitive anion channel activity
E0005253molecular_functionmonoatomic anion channel activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005765cellular_componentlysosomal membrane
E0005886cellular_componentplasma membrane
E0006820biological_processmonoatomic anion transport
E0006884biological_processcell volume homeostasis
E0006970biological_processresponse to osmotic stress
E0007283biological_processspermatogenesis
E0009986cellular_componentcell surface
E0015734biological_processtaurine transmembrane transport
E0015810biological_processaspartate transmembrane transport
E0016020cellular_componentmembrane
E0032024biological_processpositive regulation of insulin secretion
E0034214biological_processprotein hexamerization
E0034702cellular_componentmonoatomic ion channel complex
E0042802molecular_functionidentical protein binding
E0045663biological_processpositive regulation of myoblast differentiation
E0098656biological_processmonoatomic anion transmembrane transport
E0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
E0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
E1902476biological_processchloride transmembrane transport
F0001678biological_processintracellular glucose homeostasis
F0002329biological_processpre-B cell differentiation
F0005225molecular_functionvolume-sensitive anion channel activity
F0005253molecular_functionmonoatomic anion channel activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005765cellular_componentlysosomal membrane
F0005886cellular_componentplasma membrane
F0006820biological_processmonoatomic anion transport
F0006884biological_processcell volume homeostasis
F0006970biological_processresponse to osmotic stress
F0007283biological_processspermatogenesis
F0009986cellular_componentcell surface
F0015734biological_processtaurine transmembrane transport
F0015810biological_processaspartate transmembrane transport
F0016020cellular_componentmembrane
F0032024biological_processpositive regulation of insulin secretion
F0034214biological_processprotein hexamerization
F0034702cellular_componentmonoatomic ion channel complex
F0042802molecular_functionidentical protein binding
F0045663biological_processpositive regulation of myoblast differentiation
F0098656biological_processmonoatomic anion transmembrane transport
F0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
F0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
F1902476biological_processchloride transmembrane transport
G0000209biological_processprotein polyubiquitination
G0004177molecular_functionaminopeptidase activity
G0005576cellular_componentextracellular region
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006508biological_processproteolysis
G0016285molecular_functionalanyl aminopeptidase activity
G0043171biological_processpeptide catabolic process
G0070006molecular_functionmetalloaminopeptidase activity
G0070062cellular_componentextracellular exosome
G0071456biological_processcellular response to hypoxia
G1903749biological_processpositive regulation of protein localization to mitochondrion
H0000209biological_processprotein polyubiquitination
H0004177molecular_functionaminopeptidase activity
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006508biological_processproteolysis
H0016285molecular_functionalanyl aminopeptidase activity
H0043171biological_processpeptide catabolic process
H0070006molecular_functionmetalloaminopeptidase activity
H0070062cellular_componentextracellular exosome
H0071456biological_processcellular response to hypoxia
H1903749biological_processpositive regulation of protein localization to mitochondrion
I0000209biological_processprotein polyubiquitination
I0004177molecular_functionaminopeptidase activity
I0005576cellular_componentextracellular region
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006508biological_processproteolysis
I0016285molecular_functionalanyl aminopeptidase activity
I0043171biological_processpeptide catabolic process
I0070006molecular_functionmetalloaminopeptidase activity
I0070062cellular_componentextracellular exosome
I0071456biological_processcellular response to hypoxia
I1903749biological_processpositive regulation of protein localization to mitochondrion
Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVGHELAHQW
ChainResidueDetails
GVAL349-TRP358
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues3
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues15
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsSite: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsModified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"Q11011","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues138
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30095067","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30127360","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ZSU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DJB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues108
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30095067","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30127360","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ZSU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DJB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues126
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30095067","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30127360","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ZSU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DJB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues174
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues144
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30095067","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30127360","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ZSU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DJB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues138
DetailsRepeat: {"description":"LRR 1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues132
DetailsRepeat: {"description":"LRR 2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues126
DetailsRepeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues138
DetailsRepeat: {"description":"LRR 4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues132
DetailsRepeat: {"description":"LRR 5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues144
DetailsRepeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues132
DetailsRepeat: {"description":"LRR 7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues132
DetailsRepeat: {"description":"LRR 8","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues138
DetailsRepeat: {"description":"LRR 9","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues132
DetailsRepeat: {"description":"LRR 10","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues132
DetailsRepeat: {"description":"LRR 11","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues132
DetailsRepeat: {"description":"LRR 12","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues126
DetailsRepeat: {"description":"LRR 13","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues132
DetailsRepeat: {"description":"LRR 14","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues126
DetailsRepeat: {"description":"LRR 15","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues132
DetailsRepeat: {"description":"LRR 16","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues138
DetailsRepeat: {"description":"LRR 17","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues6
DetailsMotif: {"description":"Di-leucine motif","evidences":[{"source":"PubMed","id":"33139539","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues6
DetailsSite: {"description":"Required for anion selectivity","evidences":[{"source":"PubMed","id":"30095067","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2026-05-27

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