9O5E

The dimeric KICSTOR-GATOR1 supercomplex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (C, F)	GATOR complex protein NPRL3	polymer	590	65769.0	2	UniProt (Q12980)	Homo sapiens (human)	-14 gene protein,Alpha-globin regulatory element-containing gene protein,Nitrogen permease regulator 3-like protein,Protein CGTHBA
2	B, F (D, G)	GATOR complex protein NPRL2	polymer	401	45799.5	2	UniProt (Q8WTW4)	Homo sapiens (human)	Gene 21 protein,G21 protein,Nitrogen permease regulator 2-like protein,NPR2-like protein,Tumor suppressor candidate 4
3	C, G (E, I)	KICSTOR complex protein SZT2	polymer	3451	380386.5	2	UniProt (Q5T011)	Homo sapiens (human)	Seizure threshold 2 protein homolog
4	D, H (H, J)	GATOR1 complex protein DEPDC5	polymer	1621	183207.7	2	UniProt (O75140)	Homo sapiens (human)	DEP domain-containing protein 5

Sequence modifications

C, F: 1 - 569 (UniProt: Q12980)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Tyr -18	-	expression tag
Pro -17	-	expression tag
Tyr -16	-	expression tag
Asp -15	-	expression tag
Val -14	-	expression tag
Pro -13	-	expression tag
Asp -12	-	expression tag
Tyr -11	-	expression tag
Ala -10	-	expression tag
Asp -9	-	expression tag
Leu -8	-	expression tag
Asn -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag

D, G: 1 - 380 (UniProt: Q8WTW4)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Tyr -18	-	expression tag
Pro -17	-	expression tag
Tyr -16	-	expression tag
Asp -15	-	expression tag
Val -14	-	expression tag
Pro -13	-	expression tag
Asp -12	-	expression tag
Tyr -11	-	expression tag
Ala -10	-	expression tag
Asp -9	-	expression tag
Leu -8	-	expression tag
Asn -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag

E, I: 1 - 3432 (UniProt: Q5T011)

PDB	External Database	Details
Met -18	-	expression tag
Glu -17	-	expression tag
Met -16	-	expression tag
Asp -15	-	expression tag
Tyr -14	-	expression tag
Lys -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Lys -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Ala -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag

H, J: 1 - 1603 (UniProt: O75140)

PDB	External Database	Details
Met -17	-	expression tag
Gly -16	-	expression tag
Asp -15	-	expression tag
Tyr -14	-	expression tag
Lys -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Lys -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Ala -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	1350325.5
All*	Total formula weight	1350325.5

*Water molecules are not included.