9O5E

The dimeric KICSTOR-GATOR1 supercomplex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005515	molecular_function	protein binding
C	0005765	cellular_component	lysosomal membrane
C	0010508	biological_process	positive regulation of autophagy
C	0034198	biological_process	cellular response to amino acid starvation
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1990130	cellular_component	GATOR1 complex
D	0005096	molecular_function	GTPase activator activity
D	0005515	molecular_function	protein binding
D	0005765	cellular_component	lysosomal membrane
D	0005774	cellular_component	vacuolar membrane
D	0033673	biological_process	negative regulation of kinase activity
D	0034198	biological_process	cellular response to amino acid starvation
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1990130	cellular_component	GATOR1 complex
E	0005515	molecular_function	protein binding
E	0005765	cellular_component	lysosomal membrane
E	0005777	cellular_component	peroxisome
E	0007417	biological_process	central nervous system development
E	0009791	biological_process	post-embryonic development
E	0021540	biological_process	corpus callosum morphogenesis
E	0031667	biological_process	response to nutrient levels
E	0034198	biological_process	cellular response to amino acid starvation
E	0042149	biological_process	cellular response to glucose starvation
E	0061462	biological_process	protein localization to lysosome
E	0061700	cellular_component	GATOR2 complex
E	0140007	cellular_component	KICSTOR complex
E	1901668	biological_process	regulation of superoxide dismutase activity
E	1904262	biological_process	negative regulation of TORC1 signaling
E	1990130	cellular_component	GATOR1 complex
F	0005515	molecular_function	protein binding
F	0005765	cellular_component	lysosomal membrane
F	0010508	biological_process	positive regulation of autophagy
F	0034198	biological_process	cellular response to amino acid starvation
F	1904262	biological_process	negative regulation of TORC1 signaling
F	1990130	cellular_component	GATOR1 complex
G	0005096	molecular_function	GTPase activator activity
G	0005515	molecular_function	protein binding
G	0005765	cellular_component	lysosomal membrane
G	0005774	cellular_component	vacuolar membrane
G	0033673	biological_process	negative regulation of kinase activity
G	0034198	biological_process	cellular response to amino acid starvation
G	1904262	biological_process	negative regulation of TORC1 signaling
G	1990130	cellular_component	GATOR1 complex
H	0005737	cellular_component	cytoplasm
H	0005764	cellular_component	lysosome
H	0005765	cellular_component	lysosomal membrane
H	0005829	cellular_component	cytosol
H	0010508	biological_process	positive regulation of autophagy
H	0031267	molecular_function	small GTPase binding
H	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
H	0034198	biological_process	cellular response to amino acid starvation
H	0044877	molecular_function	protein-containing complex binding
H	0048471	cellular_component	perinuclear region of cytoplasm
H	1904262	biological_process	negative regulation of TORC1 signaling
H	1990130	cellular_component	GATOR1 complex
I	0005515	molecular_function	protein binding
I	0005765	cellular_component	lysosomal membrane
I	0005777	cellular_component	peroxisome
I	0007417	biological_process	central nervous system development
I	0009791	biological_process	post-embryonic development
I	0021540	biological_process	corpus callosum morphogenesis
I	0031667	biological_process	response to nutrient levels
I	0034198	biological_process	cellular response to amino acid starvation
I	0042149	biological_process	cellular response to glucose starvation
I	0061462	biological_process	protein localization to lysosome
I	0061700	cellular_component	GATOR2 complex
I	0140007	cellular_component	KICSTOR complex
I	1901668	biological_process	regulation of superoxide dismutase activity
I	1904262	biological_process	negative regulation of TORC1 signaling
I	1990130	cellular_component	GATOR1 complex
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0005765	cellular_component	lysosomal membrane
J	0005829	cellular_component	cytosol
J	0010508	biological_process	positive regulation of autophagy
J	0031267	molecular_function	small GTPase binding
J	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
J	0034198	biological_process	cellular response to amino acid starvation
J	0044877	molecular_function	protein-containing complex binding
J	0048471	cellular_component	perinuclear region of cytoplasm
J	1904262	biological_process	negative regulation of TORC1 signaling
J	1990130	cellular_component	GATOR1 complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Arginine finger","evidences":[{"source":"PubMed","id":"30651352","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Asymmetric dimethylarginine","evidences":[{"source":"PubMed","id":"38006878","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36528027","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---