9O5A

The KICSTOR-GATOR1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	GATOR complex protein NPRL2	polymer	401	45799.5	1	UniProt (Q8WTW4) Pfam (PF06218)	Homo sapiens (human)	Gene 21 protein,G21 protein,Nitrogen permease regulator 2-like protein,NPR2-like protein,Tumor suppressor candidate 4
2	B (B)	GATOR1 complex protein DEPDC5	polymer	1621	183207.7	1	UniProt (O75140) Pfam (PF23013) Pfam (PF12257) Pfam (PF00610) Pfam (PF19418)	Homo sapiens (human)	DEP domain-containing protein 5
3	C (D)	KICSTOR complex protein SZT2	polymer	3451	380386.5	1	UniProt (Q5T011)	Homo sapiens (human)	Seizure threshold 2 protein homolog
4	D (E)	KICSTOR complex protein kaptin	polymer	457	50216.5	1	UniProt (Q9Y664)	Homo sapiens (human)	Actin-associated protein 2E4
5	E (F)	KICSTOR subunit 2	polymer	466	52573.9	1	UniProt (Q96MD2) Pfam (PF09404)	Homo sapiens (human)	KICSTOR complex protein C12orf66
6	F (G)	KICSTOR complex protein ITFG2	polymer	466	51270.8	1	UniProt (Q969R8) Pfam (PF15907)	Homo sapiens (human)	Integrin-alpha FG-GAP repeat-containing protein 2
7	G (C)	GATOR complex protein NPRL3	polymer	590	65769.0	1	UniProt (Q12980) Pfam (PF03666) Pfam (PF24064)	Homo sapiens (human)	-14 gene protein,Alpha-globin regulatory element-containing gene protein,Nitrogen permease regulator 3-like protein,Protein CGTHBA

Sequence modifications

H: 1 - 380 (UniProt: Q8WTW4)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Tyr -18	-	expression tag
Pro -17	-	expression tag
Tyr -16	-	expression tag
Asp -15	-	expression tag
Val -14	-	expression tag
Pro -13	-	expression tag
Asp -12	-	expression tag
Tyr -11	-	expression tag
Ala -10	-	expression tag
Asp -9	-	expression tag
Leu -8	-	expression tag
Asn -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag

B: 1 - 1603 (UniProt: O75140)

PDB	External Database	Details
Met -17	-	expression tag
Gly -16	-	expression tag
Asp -15	-	expression tag
Tyr -14	-	expression tag
Lys -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Lys -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Ala -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag

D: -1 - 3432 (UniProt: Q5T011)

PDB	External Database	Details
Met -20	-	expression tag
Glu -19	-	expression tag
Met -18	-	expression tag
Asp -17	-	expression tag
Tyr -16	-	expression tag
Lys -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Lys -10	-	expression tag
Gly -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Ala -4	-	expression tag
Ser -3	-	expression tag
Thr -2	-	expression tag

E: 1 - 436 (UniProt: Q9Y664)

PDB	External Database	Details
Met -20	-	initiating methionine
Gly -19	-	expression tag
Tyr -18	-	expression tag
Pro -17	-	expression tag
Tyr -16	-	expression tag
Asp -15	-	expression tag
Val -14	-	expression tag
Pro -13	-	expression tag
Asp -12	-	expression tag
Tyr -11	-	expression tag
Ala -10	-	expression tag
Asp -9	-	expression tag
Leu -8	-	expression tag
Asn -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag

F: 1 - 445 (UniProt: Q96MD2)

PDB	External Database	Details
Met -20	-	initiating methionine
Gly -19	-	expression tag
Tyr -18	-	expression tag
Pro -17	-	expression tag
Tyr -16	-	expression tag
Asp -15	-	expression tag
Val -14	-	expression tag
Pro -13	-	expression tag
Asp -12	-	expression tag
Tyr -11	-	expression tag
Ala -10	-	expression tag
Asp -9	-	expression tag
Leu -8	-	expression tag
Asn -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag
Ser 443	Ala 443	variant

G: 1 - 447 (UniProt: Q969R8)

PDB	External Database	Details
Met -18	-	initiating methionine
Glu -17	-	expression tag
Gln -16	-	expression tag
Lys -15	-	expression tag
Leu -14	-	expression tag
Ile -13	-	expression tag
Ser -12	-	expression tag
Glu -11	-	expression tag
Glu -10	-	expression tag
Asp -9	-	expression tag
Leu -8	-	expression tag
Asn -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag

C: 1 - 569 (UniProt: Q12980)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Tyr -18	-	expression tag
Pro -17	-	expression tag
Tyr -16	-	expression tag
Asp -15	-	expression tag
Val -14	-	expression tag
Pro -13	-	expression tag
Asp -12	-	expression tag
Tyr -11	-	expression tag
Ala -10	-	expression tag
Asp -9	-	expression tag
Leu -8	-	expression tag
Asn -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Thr 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	829223.9
All*	Total formula weight	829223.9

*Water molecules are not included.