9O5A

The KICSTOR-GATOR1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005829	cellular_component	cytosol
B	0010508	biological_process	positive regulation of autophagy
B	0031267	molecular_function	small GTPase binding
B	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
B	0034198	biological_process	cellular response to amino acid starvation
B	0044877	molecular_function	protein-containing complex binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1990130	cellular_component	GATOR1 complex
C	0005515	molecular_function	protein binding
C	0005765	cellular_component	lysosomal membrane
C	0010508	biological_process	positive regulation of autophagy
C	0034198	biological_process	cellular response to amino acid starvation
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1990130	cellular_component	GATOR1 complex
D	0005515	molecular_function	protein binding
D	0005765	cellular_component	lysosomal membrane
D	0005777	cellular_component	peroxisome
D	0007417	biological_process	central nervous system development
D	0009791	biological_process	post-embryonic development
D	0021540	biological_process	corpus callosum morphogenesis
D	0031667	biological_process	response to nutrient levels
D	0034198	biological_process	cellular response to amino acid starvation
D	0042149	biological_process	cellular response to glucose starvation
D	0061462	biological_process	protein localization to lysosome
D	0061700	cellular_component	GATOR2 complex
D	0140007	cellular_component	KICSTOR complex
D	1901668	biological_process	regulation of superoxide dismutase activity
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1990130	cellular_component	GATOR1 complex
E	0005515	molecular_function	protein binding
E	0005765	cellular_component	lysosomal membrane
E	0030027	cellular_component	lamellipodium
E	0031941	cellular_component	filamentous actin
E	0032420	cellular_component	stereocilium
E	0034198	biological_process	cellular response to amino acid starvation
E	0042149	biological_process	cellular response to glucose starvation
E	0051015	molecular_function	actin filament binding
E	0061462	biological_process	protein localization to lysosome
E	0098871	cellular_component	postsynaptic actin cytoskeleton
E	0140007	cellular_component	KICSTOR complex
E	1904262	biological_process	negative regulation of TORC1 signaling
F	0005765	cellular_component	lysosomal membrane
F	0034198	biological_process	cellular response to amino acid starvation
F	0042149	biological_process	cellular response to glucose starvation
F	0061462	biological_process	protein localization to lysosome
F	0140007	cellular_component	KICSTOR complex
F	1903432	biological_process	regulation of TORC1 signaling
F	1904262	biological_process	negative regulation of TORC1 signaling
G	0005515	molecular_function	protein binding
G	0005654	cellular_component	nucleoplasm
G	0005765	cellular_component	lysosomal membrane
G	0005829	cellular_component	cytosol
G	0032006	biological_process	regulation of TOR signaling
G	0034198	biological_process	cellular response to amino acid starvation
G	0042149	biological_process	cellular response to glucose starvation
G	0140007	cellular_component	KICSTOR complex
G	1904262	biological_process	negative regulation of TORC1 signaling
H	0005096	molecular_function	GTPase activator activity
H	0005515	molecular_function	protein binding
H	0005765	cellular_component	lysosomal membrane
H	0005774	cellular_component	vacuolar membrane
H	0033673	biological_process	negative regulation of kinase activity
H	0034198	biological_process	cellular response to amino acid starvation
H	1904262	biological_process	negative regulation of TORC1 signaling
H	1990130	cellular_component	GATOR1 complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Arginine finger","evidences":[{"source":"PubMed","id":"30651352","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Asymmetric dimethylarginine","evidences":[{"source":"PubMed","id":"38006878","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36528027","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	29
Details	Repeat: {"description":"FG-GAP 1; atypical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	29
Details	Repeat: {"description":"FG-GAP 2; atypical"}

Chain

Residue

Details

---