9O58
Zymogen ADAM17-iRhom2 complex bound by the MEDI3622 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Disintegrin and metalloproteinase domain-containing protein 17 | polymer | 807 | 91328.7 | 1 | UniProt (P78536) Pfam (PF13574) Pfam (PF00200) Pfam (PF16698) | Homo sapiens (human) | ADAM 17,Snake venom-like protease,TNF-alpha convertase,TNF-alpha-converting enzyme |
| 2 | B (B) | GFP-iRhom2 fusion protein | polymer | 741 | 84277.5 | 1 | UniProt (P42212) UniProt (Q6PJF5) Pfam (PF01694) | Aequorea victoria (Water jellyfish Mesonema victoria) | iRhom2,Rhomboid 5 homolog 2,Rhomboid family member 2,Rhomboid veinlet-like protein 5,Rhomboid veinlet-like protein 6 |
| 3 | C (C) | MEDI3622 Fab Light Chain | polymer | 214 | 23324.9 | 1 | Homo sapiens (human) | ||
| 4 | D (D) | MEDI3622 Fab Heavy Chain | polymer | 221 | 23442.3 | 1 | Homo sapiens (human) | ||
| 5 | E (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F, G, H, I, J... (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 7 | L (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 8 | M (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 28 - 824 (UniProt: P78536)
B: 118 - 354 (UniProt: P42212)
B: 364 - 856 (UniProt: Q6PJF5)
| PDB | External Database | Details |
|---|---|---|
| Ala 406 | Glu 406 | conflict |
| Glu 825 | - | expression tag |
| Gln 826 | - | expression tag |
| Lys 827 | - | expression tag |
| Leu 828 | - | expression tag |
| Ile 829 | - | expression tag |
| Ser 830 | - | expression tag |
| Glu 831 | - | expression tag |
| Glu 832 | - | expression tag |
| Asp 833 | - | expression tag |
| Leu 834 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 116 | - | initiating methionine |
| Val 117 | - | expression tag |
| Leu 162 | Phe 46 | conflict |
| Leu 180 | Phe 64 | conflict |
| Gly 181 | Ser 65 | conflict |
| Leu 184 | Val 68 | conflict |
| Ala 188 | Ser 72 | conflict |
| Thr 269 | Met 153 | conflict |
| Ala 279 | Val 163 | conflict |
| Gly 291 | Ser 175 | conflict |
| Tyr 319 | Thr 203 | conflict |
| Lys 322 | Ala 206 | conflict |
| Leu 347 | His 231 | conflict |
| Asp 355 | - | linker |
| Tyr 356 | - | linker |
| Lys 357 | - | linker |
| Asp 358 | - | linker |
| Asp 359 | - | linker |
| Asp 360 | - | linker |
| Lys 361 | - | linker |
| Ser 362 | - | linker |
| Gly 363 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 222373.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1432.7 | |
| All* | Total formula weight | 224230.6 |
