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9O58

Zymogen ADAM17-iRhom2 complex bound by the MEDI3622 Fab

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001666biological_processresponse to hypoxia
A0002446biological_processneutrophil mediated immunity
A0002467biological_processgerminal center formation
A0002532biological_processproduction of molecular mediator involved in inflammatory response
A0002690biological_processpositive regulation of leukocyte chemotaxis
A0004175molecular_functionendopeptidase activity
A0004222molecular_functionmetalloendopeptidase activity
A0005112molecular_functionNotch binding
A0005138molecular_functioninterleukin-6 receptor binding
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005788cellular_componentendoplasmic reticulum lumen
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0005925cellular_componentfocal adhesion
A0006508biological_processproteolysis
A0006509biological_processmembrane protein ectodomain proteolysis
A0007155biological_processcell adhesion
A0007173biological_processepidermal growth factor receptor signaling pathway
A0007219biological_processNotch signaling pathway
A0007220biological_processNotch receptor processing
A0008233molecular_functionpeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008284biological_processpositive regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0009967biological_processpositive regulation of signal transduction
A0009986cellular_componentcell surface
A0010820biological_processpositive regulation of T cell chemotaxis
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016485biological_processprotein processing
A0016787molecular_functionhydrolase activity
A0017124molecular_functionSH3 domain binding
A0019955molecular_functioncytokine binding
A0023061biological_processsignal release
A0030165molecular_functionPDZ domain binding
A0030183biological_processB cell differentiation
A0030307biological_processpositive regulation of cell growth
A0030335biological_processpositive regulation of cell migration
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0032496biological_processresponse to lipopolysaccharide
A0032587cellular_componentruffle membrane
A0032722biological_processpositive regulation of chemokine production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0033025biological_processregulation of mast cell apoptotic process
A0033077biological_processT cell differentiation in thymus
A0033627biological_processcell adhesion mediated by integrin
A0035313biological_processwound healing, spreading of epidermal cells
A0042987biological_processamyloid precursor protein catabolic process
A0043120molecular_functiontumor necrosis factor binding
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0043536biological_processpositive regulation of blood vessel endothelial cell migration
A0045121cellular_componentmembrane raft
A0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
A0046872molecular_functionmetal ion binding
A0048536biological_processspleen development
A0048870biological_processcell motility
A0050830biological_processdefense response to Gram-positive bacterium
A0070573molecular_functionmetallodipeptidase activity
A0071403biological_processcellular response to high density lipoprotein particle stimulus
A0071679biological_processcommissural neuron axon guidance
A0120163biological_processnegative regulation of cold-induced thermogenesis
A0140447biological_processcytokine precursor processing
A0140448biological_processsignaling receptor ligand precursor processing
A1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
A1902945molecular_functionmetalloendopeptidase activity involved in amyloid precursor protein catabolic process
A1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
A1905564biological_processpositive regulation of vascular endothelial cell proliferation
B0004252molecular_functionserine-type endopeptidase activity
B0006091biological_processgeneration of precursor metabolites and energy
B0008218biological_processbioluminescence
B0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
CTYR192-HIS198
DTYR200-HIS206

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues160
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues251
DetailsDomain: {"description":"Peptidase M12B","evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues88
DetailsDomain: {"description":"Disintegrin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00068","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues68
DetailsRegion: {"description":"Crambin-like"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9520379","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsBinding site: {"description":"in inhibited form","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"9520379","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues9
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues266
DetailsTopological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues27
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues22
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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