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9O51

Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex in the Ca2+ free state

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Intermediate conductance calcium-activated potassium channel protein 4,Small conductance calcium-activated potassium channel protein 2 chimerapolymer43549382.24UniProt (O15554)
UniProt (Q9H2S1)
Pfam (PF03530)
Pfam (PF07885)
Pfam (PF02888)
Homo sapiens (human)SKCa 4,SKCa4,hSK4,Gardos channel,IKCa1,hIK1,KCa3.1,Putative Gardos channel,hKCa4,SK2,SKCa 2,SKCa2,KCa2.2
2E, F, G, H
(E, F, G, H)
Calmodulin-1polymer14916852.54UniProt (P0DP23)
Pfam (PF13499)
Homo sapiens (human)
3I, J
(A)
POTASSIUM IONnon-polymer39.12Chemie (K)
4K, L, M, N
(E, F, G, H)
CALCIUM IONnon-polymer40.14Chemie (CA)
Sequence modifications
A, B, C, D: 110 - 123 (UniProt: O15554)
A, B, C, D: 124 - 412 (UniProt: Q9H2S1)
A, B, C, D: 413 - 535 (UniProt: O15554)
PDBExternal DatabaseDetails
Ser 536-expression tag
Ser 537-expression tag
Ser 538-expression tag
Leu 539-expression tag
Glu 540-expression tag
Val 541-expression tag
Leu 542-expression tag
Phe 543-expression tag
Gln 544-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains8
Total formula weight264938.8
Non-Polymers*Number of molecules6
Total formula weight238.5
All*Total formula weight265177.3
*Water molecules are not included.

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PDB entries from 2025-07-23

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