9O0Q
Crystal structure of GMPPNP-bound mutant MRAS in complex with MRTX1133
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Ras-related protein M-Ras | polymer | 179 | 20469.2 | 3 | UniProt (O14807) Pfam (PF00071) | Homo sapiens (human) | Ras-related protein R-Ras3 |
| 2 | D, M, Y (A, B, C) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 3 | Chemie (GNP) | |||
| 3 | E, N, Z (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | AA, F, O (C, A, B) | 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol | non-polymer | 600.6 | 3 | Chemie (6IC) | |||
| 5 | BA, G, H, I, J... (C, A, B) | SULFATE ION | non-polymer | 96.1 | 11 | Chemie (SO4) | |||
| 6 | K, L, V, W (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 7 | CA, X (C, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 8 | DA, EA, FA (A, B, C) | water | water | 18.0 | 486 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 178 (UniProt: O14807)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Tyr 74 | Phe 74 | engineered mutation |
| His 105 | Arg 105 | engineered mutation |
| Tyr 106 | Phe 106 | engineered mutation |
| Gln 109 | Leu 109 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 61407.7 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 4937.4 | |
| All* | Total formula weight | 66345.1 |
