9NX8
Cryo-EM structure of UL5/UL52 heterodimer from Herpes Simplex Virus 1 in complex with Pritelivir and ssDNA
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | UL5 | polymer | 882 | 98842.3 | 1 | UniProt (A0A2U9A5B2) | Human alphaherpesvirus 1 (Herpes simplex virus type 1) | |
| 2 | B (B) | UL52 | polymer | 1058 | 114592.5 | 1 | UniProt (A0A2U9A692) | Human alphaherpesvirus 1 (Herpes simplex virus type 1) | |
| 3 | C (C) | DNA (5'-D(P*TP*TP*TP*T)-3') | polymer | 53 | 16060.3 | 1 | synthetic construct | ||
| 4 | D (A) | Pritelivir | non-polymer | 402.5 | 1 | Chemie (A1BXB) PubChem (491941) | |||
| 5 | E (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) PubChem (32051) |
Sequence modifications
A: 42 - 882 (UniProt: A0A2U9A5B2)
B: 1 - 1058 (UniProt: A0A2U9A692)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Ala 2 | - | expression tag |
| Ala 3 | - | expression tag |
| Ala 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Gly 6 | - | expression tag |
| Glu 7 | - | expression tag |
| Arg 8 | - | expression tag |
| Gln 9 | - | expression tag |
| Leu 10 | - | expression tag |
| Asp 11 | - | expression tag |
| Gly 12 | - | expression tag |
| Gln 13 | - | expression tag |
| Lys 14 | - | expression tag |
| Pro 15 | - | expression tag |
| Gly 16 | - | expression tag |
| Pro 17 | - | expression tag |
| Pro 18 | - | expression tag |
| His 19 | - | expression tag |
| Leu 20 | - | expression tag |
| Gln 21 | - | expression tag |
| Gln 22 | - | expression tag |
| Pro 23 | - | expression tag |
| Gly 24 | - | expression tag |
| Asp 25 | - | expression tag |
| Arg 26 | - | expression tag |
| Pro 27 | - | expression tag |
| Ala 28 | - | expression tag |
| Val 29 | - | expression tag |
| Pro 30 | - | expression tag |
| Gly 31 | - | expression tag |
| Arg 32 | - | expression tag |
| Ala 33 | - | expression tag |
| Glu 34 | - | expression tag |
| Ala 35 | - | expression tag |
| Phe 36 | - | expression tag |
| Leu 37 | - | expression tag |
| Asn 38 | - | expression tag |
| Phe 39 | - | expression tag |
| Thr 40 | - | expression tag |
| Ser 41 | - | expression tag |
| Leu 205 | Ser 164 | conflict |
| Val 690 | Gly 649 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Glu 129 | Asp 129 | conflict |
| Val 166 | Ile 166 | conflict |
| Ser 385 | Asn 385 | conflict |
| Asp 514 | Gly 514 | conflict |
| Gln 530 | Arg 530 | conflict |
| Pro 703 | Ser 703 | conflict |
| Ala 719 | Thr 719 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 229495.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 467.9 | |
| All* | Total formula weight | 229963.0 |
