9NWW
Single-particle cryo-EM structure of the first variant of mobilized colistin resistance (MCR-1) in its ligand-bound state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Probable phosphatidylethanolamine transferase Mcr-1 | polymer | 577 | 63996.9 | 1 | UniProt (A0A0R6L508) | Escherichia coli | Polymyxin resistance protein MCR-1 |
| 2 | B (C) | Fab (MR6) Light (L) Chain | polymer | 214 | 23330.9 | 1 | Homo sapiens | ||
| 3 | C (D) | Fab (MR6) Heavy (H) Chain | polymer | 235 | 24969.7 | 1 | Homo sapiens | ||
| 4 | D (B) | (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid | non-polymer | 2238.7 | 1 | Chemie (KDL) PubChem (23350883) PubChem (440886) PubChem (60101765) PubChem (9547199) PubChem (11355423) PubChem (90714308) PubChem (91820279) PubChem (5242961) PubChem (5771770) PubChem (136212440) PubChem (126455995) PubChem (131871047) PubChem (132983953) PubChem (171036006) PubChem (170907861) PubChem (172948496) PubChem (175667469) | |||
| 5 | E (B) | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 744.0 | 1 | Chemie (PEE) PubChem (108229) PubChem (44891344) PubChem (54095275) PubChem (14238554) PubChem (6437392) PubChem (9546744) PubChem (99655478) PubChem (99655479) PubChem (5909904) PubChem (9546757) PubChem (138113035) PubChem (171729549) |
Sequence modifications
B: 1 - 541 (UniProt: A0A0R6L508)
| PDB | External Database | Details |
|---|---|---|
| Met -35 | - | expression tag |
| His -34 | - | expression tag |
| His -33 | - | expression tag |
| His -32 | - | expression tag |
| His -31 | - | expression tag |
| His -30 | - | expression tag |
| His -29 | - | expression tag |
| His -28 | - | expression tag |
| His -27 | - | expression tag |
| His -26 | - | expression tag |
| His -25 | - | expression tag |
| Ser -24 | - | expression tag |
| Ser -23 | - | expression tag |
| Gly -22 | - | expression tag |
| Val -21 | - | expression tag |
| Asp -20 | - | expression tag |
| Leu -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Thr -17 | - | expression tag |
| Glu -16 | - | expression tag |
| Asn -15 | - | expression tag |
| Leu -14 | - | expression tag |
| Tyr -13 | - | expression tag |
| Phe -12 | - | expression tag |
| Gln -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Asn -9 | - | expression tag |
| Ala -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Ser -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 112297.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 2982.8 | |
| All* | Total formula weight | 115280.2 |
