9NWW
Single-particle cryo-EM structure of the first variant of mobilized colistin resistance (MCR-1) in its ligand-bound state
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| C | TYR192-HIS198 | |
| D | TYR208-HIS214 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 100 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 400 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 17 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27655155","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28059088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29079699","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GOV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GRR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K4P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LRN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YLC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YLF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LI4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"27655155","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28059088","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
