9NRJ
abTCR bound to SAR444200, a novel anti-GPC3 T-cell engager, for the treatment of GPC3+ solid tumors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | M1-specific T cell receptor alpha chain | polymer | 199 | 21782.2 | 1 | UniProt (P0DSE1) | Homo sapiens (human) | TR alpha chain TRAV27*01J42*01C*01 |
| 2 | B (B) | M1-specific T cell receptor beta chain | polymer | 242 | 27555.5 | 1 | UniProt (P0DSE2) | Homo sapiens (human) | TR beta chain TRBV19*01J2S7*01C*02 |
| 3 | C (C) | 2C04 | polymer | 114 | 12562.2 | 1 | Homo sapiens (human) | ||
| 4 | D (T) | TCE01 | polymer | 117 | 13061.5 | 1 | Homo sapiens (human) | ||
| 5 | E (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 6 | F (E) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 7 | G (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) |
Sequence modifications
A: 2 - 200 (UniProt: P0DSE1)
B: 3 - 244 (UniProt: P0DSE2)
| PDB | External Database | Details |
|---|---|---|
| Ala 92 | Gly 110 | conflict |
| Asn 111 | - | insertion |
| Cys 158 | Thr 175 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 97 | Ile 114 | conflict |
| Glu 124 | Lys 141 | conflict |
| Cys 171 | Ser 188 | conflict |
| Ser 189 | Cys 206 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 74961.4 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1581.5 | |
| All* | Total formula weight | 76542.9 |
