9NRJ
abTCR bound to SAR444200, a novel anti-GPC3 T-cell engager, for the treatment of GPC3+ solid tumors
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 184 |
| Details | Domain: {"description":"Ig-like V-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 89 |
| Details | Region: {"description":"T cell receptor alpha variable 27","evidences":[{"source":"PubMed","id":"12508121","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Region: {"description":"CDR1","evidences":[{"source":"PubMed","id":"12796775","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27036003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11096259","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Region: {"description":"CDR2","evidences":[{"source":"PubMed","id":"12796775","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27036003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11096259","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 11 |
| Details | Region: {"description":"CDR3","evidences":[{"source":"PubMed","id":"12796775","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1833769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27036003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29997621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7807026","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | Region: {"description":"T cell receptor alpha joining 42","evidences":[{"source":"PubMed","id":"12508121","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"UniProtKB","id":"P01848","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 109 |
| Details | Domain: {"description":"Ig-like C1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 92 |
| Details | Region: {"description":"T cell receptor beta variable 19","evidences":[{"source":"PubMed","id":"1833769","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Region: {"description":"CDR1","evidences":[{"source":"PubMed","id":"11096259","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 5 |
| Details | Region: {"description":"CDR2","evidences":[{"source":"PubMed","id":"11096259","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 12 |
| Details | Region: {"description":"CDR3","evidences":[{"source":"PubMed","id":"1833769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29997621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7807026","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 14 |
| Details | Region: {"description":"T cell receptor beta joining 2-7","evidences":[{"source":"PubMed","id":"1833769","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27036003","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
