9NFQ
Crystal structure of CRBN-DDB1 and MRT-3486 in complex with NEK7
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA damage-binding protein 1 | polymer | 1140 | 127097.5 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF23726) Pfam (PF03178) | Homo sapiens (human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
| 2 | B (B) | Protein cereblon | polymer | 442 | 50603.7 | 1 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) | Homo sapiens (human) | |
| 3 | C (C) | Serine/threonine-protein kinase Nek7 | polymer | 304 | 34841.2 | 1 | UniProt (Q8TDX7) Pfam (PF00069) | Homo sapiens (human) | Never in mitosis A-related kinase 7,NimA-related protein kinase 7 |
| 4 | D (B) | (3S)-N-{[(4R)-3-(2,4-dioxo-1,3-diazinan-1-yl)imidazo[1,2-a]pyridin-7-yl]methyl}-2-(phenylmethanesulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | non-polymer | 572.6 | 1 | Chemie (A1BX6) | |||
| 5 | E (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | F (C) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 7 | G (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
C: 1 - 302 (UniProt: Q8TDX7)
| PDB | External Database | Details |
|---|---|---|
| Leu 303 | - | expression tag |
| Glu 304 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 212542.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1089.5 | |
| All* | Total formula weight | 213631.9 |
