9ND3

JAK2 pseudokinase domain in complex with diaminotriazole inhibitor

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein kinase JAK2	polymer	283	32740.5	1	UniProt (O60674) Pfam (PF07714)	Homo sapiens (human)	Janus kinase 2,JAK-2
2	B (A)	N-[(1r,4r)-4-{3-[5-amino-3-(4-sulfamoylanilino)-1H-1,2,4-triazole-1-carbonyl]-2,4-difluorophenyl}cyclohexyl]prop-2-enamide	non-polymer		545.6	1	Chemie (A1BW6)
3	C (A)	water	water		18.0	278	Chemie (HOH)

Sequence modifications

A: 536 - 812 (UniProt: O60674)

PDB	External Database	Details
His 794	Phe 794	conflict
His 813	-	expression tag
His 814	-	expression tag
His 815	-	expression tag
His 816	-	expression tag
His 817	-	expression tag
His 818	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	32740.5
Non-Polymers*	Number of molecules	1
	Total formula weight	545.6
All*	Total formula weight	33286.1

*Water molecules are not included.