9N9N
Crystal structure of KRAS(G12C) bound to the cyclic peptide UNC10415730A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isoform 2B of GTPase KRas | polymer | 171 | 19446.0 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | C, D (C, D) | cyclic peptide UNC10415730A | polymer | 13 | 1503.1 | 2 | synthetic construct | ||
| 3 | E, H (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 4 | F, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | G, J, K (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) PubChem (753) | |||
| 6 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 279 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 41898.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1211.3 | |
| All* | Total formula weight | 43109.5 |
