9N8J
Stabilized tandem antigen chimera of Pfs230 and Pfs48/45 bound by potent mAbs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | RUPA-97 Fab Heavy chain | polymer | 227 | 24074.9 | 1 | Homo sapiens | ||
| 2 | B (C) | RUPA-97 Fab Kappa chain | polymer | 215 | 23511.2 | 1 | Homo sapiens | ||
| 3 | C (D) | RUPA-44 Fab Heavy chain | polymer | 230 | 24277.3 | 1 | Homo sapiens | ||
| 4 | D (E) | RUPA-44 Fab Kappa chain | polymer | 214 | 23483.1 | 1 | Homo sapiens | ||
| 5 | E (F) | TB31F Fab Heavy chain | polymer | 222 | 23841.7 | 1 | Rattus | ||
| 6 | F (G) | TB31F Fab Lambda chain | polymer | 216 | 23256.6 | 1 | Rattus | ||
| 7 | G (H) | LMIV230-01 Fab Heavy chain | polymer | 221 | 23340.3 | 1 | Homo sapiens | ||
| 8 | H (I) | LMIV230-01 Fab Kappa chain | polymer | 215 | 23754.6 | 1 | Homo sapiens | ||
| 9 | I (X) | Gametocyte surface protein P230,Gametocyte surface protein P45/48 | polymer | 327 | 36844.5 | 1 | UniProt (Q8I6T1) UniProt (P68874) Pfam (PF07422) | Plasmodium falciparum (malaria parasite P. falciparum) | |
| 10 | J (A) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) |
Sequence modifications
X: 1 - 187 (UniProt: P68874)
X: 188 - 315 (UniProt: Q8I6T1)
| PDB | External Database | Details |
|---|---|---|
| Glu -2 | - | expression tag |
| Thr -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Gln 34 | Asn 585 | conflict |
| Asn 68 | Leu 619 | conflict |
| Lys 117 | Tyr 668 | conflict |
| Lys 120 | Leu 671 | conflict |
| Thr 146 | His 697 | conflict |
| - | Asn 732 | deletion |
| Lys 183 | Asn 735 | conflict |
| Gln 186 | Ala 738 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Pro 194 | Lys 307 | conflict |
| Tyr 195 | His 308 | conflict |
| Lys 196 | Thr 309 | conflict |
| Ser 198 | Thr 311 | conflict |
| Thr 222 | Lys 335 | conflict |
| Asp 224 | Asn 337 | conflict |
| Val 225 | His 338 | conflict |
| Trp 226 | Leu 339 | conflict |
| Asn 267 | Asp 380 | conflict |
| Ile 275 | Glu 388 | conflict |
| Tyr 284 | Gly 397 | conflict |
| Lys 286 | Val 399 | conflict |
| Val 289 | Ile 402 | conflict |
| Gly 316 | - | expression tag |
| Thr 317 | - | expression tag |
| Lys 318 | - | expression tag |
| His 319 | - | expression tag |
| His 320 | - | expression tag |
| His 321 | - | expression tag |
| His 322 | - | expression tag |
| His 323 | - | expression tag |
| His 324 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 226384.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 367.3 | |
| All* | Total formula weight | 226751.6 |
