9N4N
Composite map for GluK2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glutamate receptor ionotropic, kainate 2 | polymer | 908 | 102510.0 | 4 | UniProt (P42260) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluK2,Glutamate receptor 6,GluR-6,GluR6 |
| 2 | E, H, J, M (E, H, J, M) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 4 | In PDB GlyTouCan (G22768VO) | |||
| 3 | F, G, K, L (F, G, K, L) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 4 | I, N (I, N) | beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G31886NL) | |||
| 5 | AA, LA, O, WA (B, C, A, D) | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE | non-polymer | 213.2 | 4 | Chemie (KAI) PubChem (23616889) PubChem (45039619) PubChem (101994997) PubChem (135037246) PubChem (6603893) PubChem (3816) PubChem (10255) PubChem (73345) PubChem (3083828) PubChem (5317452) PubChem (5318769) PubChem (6453379) PubChem (6604705) PubChem (10036135) PubChem (11095940) | |||
| 6 | BA, CA, DA, JA, MA... (B, C, A, D) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 16 | Chemie (POV) PubChem (168614) PubChem (6070971) PubChem (65167) PubChem (5497103) PubChem (6436017) PubChem (6506401) PubChem (10908846) | |||
| 7 | AB, BB, CB, DB, EA... (D, B, C, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) | |||
| 8 | IA, KA, VA, Z (B, C, D, A) | 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide | non-polymer | 242.3 | 4 | Chemie (2J9) PubChem (67531324) |
Sequence modifications
A, B, C, D: 1 - 908 (UniProt: P42260)
| PDB | External Database | Details |
|---|---|---|
| Val 567 | Ile 567 | conflict |
| Cys 571 | Tyr 571 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 410039.9 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 6838.3 | |
| Non-Polymers* | Number of molecules | 42 |
| Total formula weight | 17965.0 | |
| All* | Total formula weight | 434843.1 |
