Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9N4N

Composite map for GluK2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	132
Details	Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"PubMed","id":"38778115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39592599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B38","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B39","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	80
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"38778115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39592599","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8163463","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"9B36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B38","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B39","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	72
Details	Intramembrane: {"description":"Helical; Name=M2","evidences":[{"source":"PubMed","id":"38778115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39592599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B38","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B39","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"38778115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39592599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B38","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B39","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	120
Details	Transmembrane: {"description":"Helical; Name=M3","evidences":[{"source":"PubMed","id":"38778115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39592599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B38","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B39","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	616
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"38778115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39592599","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8163463","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"9B36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B38","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B39","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	96
Details	Transmembrane: {"description":"Helical; Name=M4","evidences":[{"source":"PubMed","id":"38778115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39592599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B38","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B39","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15721240","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17115050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39592599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1S50","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I0B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I0C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B38","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B39","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"UniProtKB","id":"Q13002","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21791290","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	16
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15677325","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15677325","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8163463","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)