9MW3

Structure of SARM1 TIR domain bound to G2756

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	NAD(+) hydrolase SARM1	polymer	143	16205.6	2	UniProt (Q6SZW1) Pfam (PF13676)	Homo sapiens (human)	NADase SARM1,hSARM1,NADP(+) hydrolase SARM1,Sterile alpha and Armadillo repeat protein,Sterile alpha and TIR motif-containing protein 1,Sterile alpha motif domain-containing protein 2,MyD88-5,SAM domain-containing protein 2,Tir-1 homolog,HsTIR
2	C, D (A, B)	[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-[4-[5-[(4~{S})-4-(4-fluorophenyl)-2-oxidanylidene-piperidin-1-yl]pyridin-2-yl]pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate	non-polymer		889.7	2	Chemie (A1BTR)
3	E, F (A, B)	water	water		18.0	156	Chemie (HOH)

Sequence modifications

A, B: 560 - 700 (UniProt: Q6SZW1)

PDB	External Database	Details
Gly 558	-	expression tag
Ser 559	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	32411.1
Non-Polymers*	Number of molecules	2
	Total formula weight	1779.4
All*	Total formula weight	34190.5

*Water molecules are not included.