9MS2
Crystal structure of human CYP3A5 in complex with SJYHJ-111
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cytochrome P450 3A5 | polymer | 480 | 54862.6 | 2 | UniProt (P20815) Pfam (PF00067) | Homo sapiens (human) | CYPIIIA5,Cytochrome P450 HLp2,Cytochrome P450-PCN3 |
| 2 | C, K (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, L (A, B) | N'-(2-chlorophenyl)-N-[(3-hydroxyphenyl)methyl]-N-[(2P)-2-(1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]urea | non-polymer | 486.9 | 2 | Chemie (A1BNX) | |||
| 4 | E, F, G, I, M... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 5 | H, Q, R, S (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 6 | J (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | T, U (A, B) | water | water | 18.0 | 327 | Chemie (HOH) |
Sequence modifications
A, B: 24 - 497 (UniProt: P20815)
| PDB | External Database | Details |
|---|---|---|
| Met 22 | - | initiating methionine |
| Ala 23 | - | expression tag |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
| His 500 | - | expression tag |
| His 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 109725.2 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3223.8 | |
| All* | Total formula weight | 112949.0 |
