9MS2

Crystal structure of human CYP3A5 in complex with SJYHJ-111

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002933	biological_process	lipid hydroxylation
A	0004497	molecular_function	monooxygenase activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008210	biological_process	estrogen metabolic process
A	0008401	molecular_function	retinoic acid 4-hydroxylase activity
A	0009822	biological_process	alkaloid catabolic process
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0019825	molecular_function	oxygen binding
A	0042178	biological_process	xenobiotic catabolic process
A	0042572	biological_process	retinol metabolic process
A	0042573	biological_process	retinoic acid metabolic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046222	biological_process	aflatoxin metabolic process
A	0046872	molecular_function	metal ion binding
A	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
A	0070989	biological_process	oxidative demethylation
A	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
A	0101021	molecular_function	estrogen 2-hydroxylase activity
B	0002933	biological_process	lipid hydroxylation
B	0004497	molecular_function	monooxygenase activity
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006629	biological_process	lipid metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0008202	biological_process	steroid metabolic process
B	0008210	biological_process	estrogen metabolic process
B	0008401	molecular_function	retinoic acid 4-hydroxylase activity
B	0009822	biological_process	alkaloid catabolic process
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
B	0019825	molecular_function	oxygen binding
B	0042178	biological_process	xenobiotic catabolic process
B	0042572	biological_process	retinol metabolic process
B	0042573	biological_process	retinoic acid metabolic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046222	biological_process	aflatoxin metabolic process
B	0046872	molecular_function	metal ion binding
B	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
B	0070989	biological_process	oxidative demethylation
B	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
B	0101021	molecular_function	estrogen 2-hydroxylase activity

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGtGPRNCIG

Chain	Residue	Details
A	PHE434-GLY443

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	CYS441
B	CYS441

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