9MP0
The cryo-EM structure of the human DNA methyltransferases DNMT3A2 and DNMT3L dodecamer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (L, M, N, O, R...) | DNA (cytosine-5)-methyltransferase 3A | polymer | 689 | 77914.7 | 8 | UniProt (Q9Y6K1) Pfam (PF00855) Pfam (PF17980) Pfam (PF21255) Pfam (PF00145) | Homo sapiens (human) | Dnmt3a,DNA methyltransferase HsaIIIA,M.HsaIIIA |
| 2 | I, J (P, Q) | DNA (cytosine-5)-methyltransferase 3-like | polymer | 386 | 43530.6 | 2 | UniProt (Q9UJW3) Pfam (PF17980) Pfam (PF21255) | Homo sapiens (human) | |
| 3 | AA, BA, CA, EA, FA... (R, S, T, L, U...) | ZINC ION | non-polymer | 65.4 | 30 | Chemie (ZN) | |||
| 4 | DA, HA, LA, N, PA... (R, S, T, L, U...) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 8 | Chemie (SAH) |
Sequence modifications
P, Q: 1 - 386 (UniProt: Q9UJW3)
| PDB | External Database | Details |
|---|---|---|
| Gly 278 | Arg 278 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 710379.0 | |
| Non-Polymers* | Number of molecules | 38 |
| Total formula weight | 5037.6 | |
| All* | Total formula weight | 715416.5 |
