9MP0

The cryo-EM structure of the human DNA methyltransferases DNMT3A2 and DNMT3L dodecamer

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0000792	cellular_component	heterochromatin
P	0000794	cellular_component	condensed nuclear chromosome
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
P	0007141	biological_process	male meiosis I
P	0007283	biological_process	spermatogenesis
P	0008047	molecular_function	enzyme activator activity
P	0008270	molecular_function	zinc ion binding
P	0010468	biological_process	regulation of gene expression
P	0019899	molecular_function	enzyme binding
P	0030154	biological_process	cell differentiation
P	0035098	cellular_component	ESC/E(Z) complex
P	0045814	biological_process	negative regulation of gene expression, epigenetic
P	0045892	biological_process	negative regulation of DNA-templated transcription
P	0046872	molecular_function	metal ion binding
P	0048863	biological_process	stem cell differentiation
P	0071514	biological_process	genomic imprinting
P	0090310	biological_process	negative regulation of DNA methylation-dependent heterochromatin formation
P	0141005	biological_process	transposable element silencing by heterochromatin formation
P	0141196	biological_process	transposable element silencing by piRNA-mediated DNA methylation
Q	0000792	cellular_component	heterochromatin
Q	0000794	cellular_component	condensed nuclear chromosome
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
Q	0007141	biological_process	male meiosis I
Q	0007283	biological_process	spermatogenesis
Q	0008047	molecular_function	enzyme activator activity
Q	0008270	molecular_function	zinc ion binding
Q	0010468	biological_process	regulation of gene expression
Q	0019899	molecular_function	enzyme binding
Q	0030154	biological_process	cell differentiation
Q	0035098	cellular_component	ESC/E(Z) complex
Q	0045814	biological_process	negative regulation of gene expression, epigenetic
Q	0045892	biological_process	negative regulation of DNA-templated transcription
Q	0046872	molecular_function	metal ion binding
Q	0048863	biological_process	stem cell differentiation
Q	0071514	biological_process	genomic imprinting
Q	0090310	biological_process	negative regulation of DNA methylation-dependent heterochromatin formation
Q	0141005	biological_process	transposable element silencing by heterochromatin formation
Q	0141196	biological_process	transposable element silencing by piRNA-mediated DNA methylation

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DlVigGsPCnDLS

Chain	Residue	Details
L	ASP702-SER714

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1320
Details	Domain: {"description":"ADD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00865","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	300
Details	Zinc finger: {"description":"GATA-type; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00865","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	560
Details	Zinc finger: {"description":"PHD-type; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00865","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	736
Details	Region: {"description":"Interaction with the PRC2/EED-EZH2 complex","evidences":[{"source":"UniProtKB","id":"O88508","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01016","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10018","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17713477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QRV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"S-methylcysteine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"O88508","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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