9MJA

PARP1 ART in complex with HPF1 and EB47

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Poly [ADP-ribose] polymerase 1	polymer	1034	115433.4	1	UniProt (P09874) Pfam (PF00645) Pfam (PF21728) Pfam (PF08063) Pfam (PF00533) Pfam (PF05406) Pfam (PF02877) Pfam (PF00644)	Homo sapiens (human)	PARP-1,ADP-ribosyltransferase diphtheria toxin-like 1,ARTD1,DNA ADP-ribosyltransferase PARP1,NAD(+) ADP-ribosyltransferase 1,ADPRT 1,Poly[ADP-ribose] synthase 1,Protein poly-ADP-ribosyltransferase PARP1
2	B (B)	Histone PARylation factor 1	polymer	347	39582.2	1	UniProt (Q9NWY4) Pfam (PF10228)	Homo sapiens (human)
3	C (A)	2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide	non-polymer		537.5	1	Chemie (UHB)

Sequence modifications

A: 1 - 1014 (UniProt: P09874)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

B: 1 - 346 (UniProt: Q9NWY4)

PDB	External Database	Details
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	155015.6
Non-Polymers*	Number of molecules	1
	Total formula weight	537.5
All*	Total formula weight	155553.1

*Water molecules are not included.