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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9MJA

PARP1 ART in complex with HPF1 and EB47

Functional Information from GO Data
ChainGOidnamespacecontents
A0000012biological_processsingle strand break repair
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000723biological_processtelomere maintenance
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0001650cellular_componentfibrillar center
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003684molecular_functiondamaged DNA binding
A0003723molecular_functionRNA binding
A0003950molecular_functionNAD+ poly-ADP-ribosyltransferase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005654cellular_componentnucleoplasm
A0005667cellular_componenttranscription regulator complex
A0005694cellular_componentchromosome
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006281biological_processDNA repair
A0006302biological_processdouble-strand break repair
A0006366biological_processtranscription by RNA polymerase II
A0006471biological_processobsolete protein ADP-ribosylation
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007005biological_processmitochondrion organization
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0008047molecular_functionenzyme activator activity
A0008270molecular_functionzinc ion binding
A0010332biological_processresponse to gamma radiation
A0010613biological_processpositive regulation of cardiac muscle hypertrophy
A0016020cellular_componentmembrane
A0016051biological_processcarbohydrate biosynthetic process
A0016540biological_processprotein autoprocessing
A0016604cellular_componentnuclear body
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0023019biological_processsignal transduction involved in regulation of gene expression
A0030225biological_processmacrophage differentiation
A0030331molecular_functionnuclear estrogen receptor binding
A0030592biological_processDNA ADP-ribosylation
A0031491molecular_functionnucleosome binding
A0031625molecular_functionubiquitin protein ligase binding
A0032042biological_processmitochondrial DNA metabolic process
A0032786biological_processpositive regulation of DNA-templated transcription, elongation
A0032869biological_processcellular response to insulin stimulus
A0032880biological_processregulation of protein localization
A0032991cellular_componentprotein-containing complex
A0032993cellular_componentprotein-DNA complex
A0033148biological_processpositive regulation of intracellular estrogen receptor signaling pathway
A0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
A0034599biological_processcellular response to oxidative stress
A0034644biological_processcellular response to UV
A0035861cellular_componentsite of double-strand break
A0036211biological_processprotein modification process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042826molecular_functionhistone deacetylase binding
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043504biological_processmitochondrial DNA repair
A0043596cellular_componentnuclear replication fork
A0044378molecular_functionnon-sequence-specific DNA binding, bending
A0045188biological_processregulation of circadian sleep/wake cycle, non-REM sleep
A0045471biological_processresponse to ethanol
A0045824biological_processnegative regulation of innate immune response
A0045892biological_processnegative regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046697biological_processdecidualization
A0051287molecular_functionNAD binding
A0051901biological_processpositive regulation of mitochondrial depolarization
A0060391biological_processpositive regulation of SMAD protein signal transduction
A0060545biological_processpositive regulation of necroptotic process
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070212biological_processprotein poly-ADP-ribosylation
A0070213biological_processprotein auto-ADP-ribosylation
A0070412molecular_functionR-SMAD binding
A0071168biological_processprotein localization to chromatin
A0071169biological_processestablishment of protein localization to chromatin
A0071294biological_processcellular response to zinc ion
A0071560biological_processcellular response to transforming growth factor beta stimulus
A0071932biological_processreplication fork reversal
A0090734cellular_componentsite of DNA damage
A0140294molecular_functionNAD DNA ADP-ribosyltransferase activity
A0140537molecular_functiontranscription regulator activator activity
A0140805molecular_functionNAD+-protein-serine ADP-ribosyltransferase activity
A0140806molecular_functionNAD+-protein-aspartate ADP-ribosyltransferase activity
A0140807molecular_functionNAD+-protein-glutamate ADP-ribosyltransferase activity
A0140808molecular_functionNAD+-protein-tyrosine ADP-ribosyltransferase activity
A0140815molecular_functionNAD+-protein-histidine ADP-ribosyltransferase activity
A0140816molecular_functionNAD+-histone H2BS6 serine ADP-ribosyltransferase activity
A0140817molecular_functionNAD+-histone H3S10 serine ADP-ribosyltransferase activity
A0140822molecular_functionNAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity
A0160049biological_processnegative regulation of cGAS/STING signaling pathway
A1900182biological_processpositive regulation of protein localization to nucleus
A1901701biological_processcellular response to oxygen-containing compound
A1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
A1904044biological_processresponse to aldosterone
A1904178biological_processnegative regulation of adipose tissue development
A1904357biological_processnegative regulation of telomere maintenance via telomere lengthening
A1904646biological_processcellular response to amyloid-beta
A1904762biological_processpositive regulation of myofibroblast differentiation
A1905051biological_processregulation of base-excision repair
A1905168biological_processpositive regulation of double-strand break repair via homologous recombination
A1990090biological_processcellular response to nerve growth factor stimulus
A1990165molecular_functionsingle-strand break-containing DNA binding
A1990404molecular_functionNAD+-protein mono-ADP-ribosyltransferase activity
A1990966biological_processATP generation from poly-ADP-D-ribose
A2001170biological_processnegative regulation of ATP biosynthetic process
B0000785cellular_componentchromatin
B0003682molecular_functionchromatin binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005694cellular_componentchromosome
B0006281biological_processDNA repair
B0006302biological_processdouble-strand break repair
B0006974biological_processDNA damage response
B0010835biological_processregulation of protein ADP-ribosylation
B0042393molecular_functionhistone binding
B0072572molecular_functionpoly-ADP-D-ribose binding
B0090734cellular_componentsite of DNA damage
B0140768molecular_functionprotein ADP-ribosyltransferase-substrate adaptor activity
B0140861biological_processDNA repair-dependent chromatin remodeling
Functional Information from PROSITE/UniProt
site_idPS00347
Number of Residues36
DetailsZF_PARP_1 Zinc finger poly(ADP-ribose) polymerase (PARP)-type signature. CKkCsesIpKdslRmaimvqspmfdgkvph..WYHfsC
ChainResidueDetails
ACYS21-CYS56
ACYS125-CYS162
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues226
DetailsDomain: {"description":"PARP catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00397","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsActive site: {"description":"For poly [ADP-ribose] polymerase activity","evidences":[{"source":"PubMed","id":"32028527","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7852410","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9315851","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9UGN5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"32028527","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33589610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33683197","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"ADP-ribosylserine","evidences":[{"source":"PubMed","id":"30257210","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"PolyADP-ribosyl aspartic acid","evidences":[{"source":"PubMed","id":"33589610","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"ADP-ribosyltyrosine","evidences":[{"source":"PubMed","id":"29954836","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30257210","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"33589610","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2026-05-06

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