9MIR

CryoEM structure of ALK3-ActRIIB bound to BMP6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, D)	receptor protein serine/threonine kinase	polymer	145	15899.0	2	UniProt (A0A8C2MQM3) Pfam (PF01064) UniProt (by SIFTS) (A0AAQ5BGM0)	Homo sapiens (human)
2	C, E (E, B)	Bone Morphogenetic Protein 6 (BMP6)	polymer	104	11776.6	2	Pfam (PF00019) UniProt (by SIFTS) (G1RLU5)	Homo sapiens (human)
3	D, F (F, A)	ActRIIB	polymer	133	14933.4	2	Pfam (PF01064) UniProt (by SIFTS) (A0A7E6E4Z1)	Homo sapiens (human)
4	G, H, J, K (G, H, J, K)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	4	In PDB GlyTouCan (G15407YE)
5	I, L (I, L)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
6	M, N (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

C, D: 25 - 153 (UniProt: A0A8C2MQM3)

PDB	External Database	Details
Asp 154	-	expression tag
Lys 155	-	expression tag
Thr 156	-	expression tag
His 157	-	expression tag
Thr 158	-	expression tag
Cys 159	-	expression tag
Pro 160	-	expression tag
Pro 161	-	expression tag
Cys 162	-	expression tag
Pro 163	-	expression tag
Ala 164	-	expression tag
Pro 165	-	expression tag
Glu 166	-	expression tag
Leu 167	-	expression tag
Leu 168	-	expression tag
Gly 169	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	85217.8
Branched	Number of molecules	6
	Total formula weight	3195.0
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	88855.2

*Water molecules are not included.