9M49
Cryo-EM structure of 6:2 nsp15/dsRNA complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, I... (A, C, E, F, B...) | Uridylate-specific endoribonuclease nsp15 | polymer | 346 | 38786.1 | 6 | UniProt (P0DTD1) Pfam (PF19219) Pfam (PF19216) Pfam (PF19215) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | NendoU,Non-structural protein 15,nsp15 |
| 2 | E, G (G, I) | RNA (31-MER) | polymer | 31 | 9853.8 | 2 | Severe acute respiratory syndrome coronavirus 2 | ||
| 3 | F, H (H, J) | RNA (31-MER) | polymer | 31 | 9842.9 | 2 | Severe acute respiratory syndrome coronavirus 2 | ||
| 4 | K, L (G, I) | COBALT (II) ION | non-polymer | 58.9 | 2 | Chemie (CO) |
Sequence modifications
A, C, E, F, B, D: 1 - 346 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ala 234 | His 6686 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 272110.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 117.9 | |
| All* | Total formula weight | 272228.1 |
