9LZ1
Cryo-EM structure of PTH1R-beta-arrestin1 complex in state 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Fab30 heavy chain | polymer | 160 | 17147.0 | 1 | Mus musculus | ||
| 2 | B (L) | Fab30 light chain | polymer | 215 | 23435.1 | 1 | Mus musculus | ||
| 3 | C (P) | Long-acting PTH | polymer | 36 | 4274.0 | 1 | synthetic construct | ||
| 4 | D (R) | Parathyroid hormone/parathyroid hormone-related peptide receptor | polymer | 483 | 55297.4 | 1 | UniProt (Q03431) | Homo sapiens (human) | PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor |
| 5 | E (A) | Beta-arrestin-1 | polymer | 393 | 44281.5 | 1 | UniProt (P17870) | Bos taurus (domestic cattle) | Arrestin beta-1,Arrestin-2 |
Sequence modifications
R: 27 - 509 (UniProt: Q03431)
A: 1 - 393 (UniProt: P17870)
| PDB | External Database | Details |
|---|---|---|
| Ala 188 | Gly 188 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Glu 169 | Arg 169 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 144435.0 | |
| All* | Total formula weight | 144435.0 |
