9LZ1
Cryo-EM structure of PTH1R-beta-arrestin1 complex in state 2
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR193-HIS199 |
| site_id | PS00295 |
| Number of Residues | 19 |
| Details | ARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL |
| Chain | Residue | Details |
| A | PHE61-LEU79 |
| site_id | PS00649 |
| Number of Residues | 25 |
| Details | G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. ClpeWDhil.CWplGapgevvavpCP |
| Chain | Residue | Details |
| R | CYS108-PRO132 |
| site_id | PS00650 |
| Number of Residues | 16 |
| Details | G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGFFVaIIYCFcNgeV |
| Chain | Residue | Details |
| R | GLN451-VAL466 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30975883","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30975883","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30975883","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30975883","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30975883","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30975883","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"30975883","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"30975883","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"30975883","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NBI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | Motif: {"description":"Important for interaction with G proteins"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 41 |
| Details | Region: {"description":"Interaction with CHRM2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
