9LWY

Crystal structure of human WDR5 in complex with compound 4

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	WD repeat-containing protein 5	polymer	334	36693.5	1	UniProt (P61964) Pfam (PF25175)	Homo sapiens (human)	BMP2-induced 3-kb gene protein
2	B (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
3	C (A)	4-[[2-(6-fluoranyl-2-methyl-pyridin-3-yl)-6-(5-methyl-1,3-thiazol-2-yl)pyridin-4-yl]methyl]-1-methyl-imidazol-2-amine	non-polymer		394.5	1	Chemie (A1EMB)
4	D (A)	water	water		18.0	277	Chemie (HOH)

Sequence modifications

A: 22 - 334 (UniProt: P61964)

PDB	External Database	Details
Met 1	-	initiating methionine
Gly 2	-	expression tag
Ser 3	-	expression tag
Ser 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Ser 11	-	expression tag
Ser 12	-	expression tag
Gly 13	-	expression tag
Leu 14	-	expression tag
Val 15	-	expression tag
Pro 16	-	expression tag
Arg 17	-	expression tag
Gly 18	-	expression tag
Ser 19	-	expression tag
His 20	-	expression tag
Met 21	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36693.5
Non-Polymers*	Number of molecules	2
	Total formula weight	486.6
All*	Total formula weight	37180.1

*Water molecules are not included.