9LUS

Structure of human G9a SET-domain in complex with FLAV27 inhibitor

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Histone-lysine N-methyltransferase EHMT2	polymer	300	34494.0	2	UniProt (Q96KQ7) Pfam (PF05033) Pfam (PF00856)	Homo sapiens (human)	Euchromatic histone-lysine N-methyltransferase 2,HLA-B-associated transcript 8,Histone H3-K9 methyltransferase 3,H3-K9-HMTase 3,Lysine N-methyltransferase 1C,Protein G9a
2	C, E (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, F (A, B)	3-[1-[[(2~{S})-4-(phenylmethyl)-1,4-oxazepan-2-yl]methyl]piperidin-4-yl]phenol	non-polymer		380.5	2	Chemie (A1L7O)
4	G, H (A, B)	water	water		18.0	38	Chemie (HOH)

Sequence modifications

A, B: 913 - 1193 (UniProt: Q96KQ7)

PDB	External Database	Details
Met 894	-	initiating methionine
Gly 895	-	expression tag
Ser 896	-	expression tag
Ser 897	-	expression tag
His 898	-	expression tag
His 899	-	expression tag
His 900	-	expression tag
His 901	-	expression tag
His 902	-	expression tag
His 903	-	expression tag
Ser 904	-	expression tag
Ser 905	-	expression tag
Gly 906	-	expression tag
Leu 907	-	expression tag
Val 908	-	expression tag
Pro 909	-	expression tag
Arg 910	-	expression tag
Gly 911	-	expression tag
Ser 912	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68988.0
Non-Polymers*	Number of molecules	4
	Total formula weight	891.9
All*	Total formula weight	69879.9

*Water molecules are not included.