9LOI

Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist SD-16

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Aryl hydrocarbon receptor nuclear translocator	polymer	384	43437.4	1	UniProt (P53762) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598)	Mus musculus (house mouse)	ARNT protein,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF-1-beta,HIF1-beta
2	B (B)	Endothelial PAS domain-containing protein 1	polymer	368	42272.1	1	UniProt (P97481) Pfam (PF23171) Pfam (PF00989) Pfam (PF14598)	Mus musculus (house mouse)	EPAS-1,HIF-1-alpha-like factor,HLF,mHLF,HIF-related factor,HRF,Hypoxia-inducible factor 2-alpha,HIF-2-alpha,HIF2-alpha
3	C (B)	6-chloranyl-1,1-bis(oxidanylidene)-~{N}-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine	non-polymer		361.8	1	Chemie (A1EKA)
4	D, E (A, B)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A: 82 - 464 (UniProt: P53762)

PDB	External Database	Details
Met 81	-	initiating methionine

B: 3 - 362 (UniProt: P97481)

PDB	External Database	Details
Met 2	-	initiating methionine
Glu 363	-	expression tag
His 364	-	expression tag
His 365	-	expression tag
His 366	-	expression tag
His 367	-	expression tag
His 368	-	expression tag
His 369	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85709.5
Non-Polymers*	Number of molecules	1
	Total formula weight	361.8
All*	Total formula weight	86071.3

*Water molecules are not included.