9LI2

DCA-bound state of hPAC structure

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Proton-activated chloride channel	polymer	391	44681.9	3	UniProt (Q9H813) Pfam (PF15122)	Homo sapiens (human)	PAC,hPAC,Acid-sensitive outwardly-rectifying anion channel,ASOR,Proton-activated outwardly rectifying anion channel,PAORAC,Transmembrane protein 206,hTMEM206
2	D, E, F (A, B, C)	(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID	non-polymer		392.6	3	Chemie (DXC)

Sequence modifications

A, B, C: 1 - 350 (UniProt: Q9H813)

PDB	External Database	Details
Met -40	-	initiating methionine
Asp -39	-	expression tag
Tyr -38	-	expression tag
Lys -37	-	expression tag
Asp -36	-	expression tag
Asp -35	-	expression tag
Asp -34	-	expression tag
Asp -33	-	expression tag
Lys -32	-	expression tag
Trp -31	-	expression tag
Ser -30	-	expression tag
His -29	-	expression tag
Pro -28	-	expression tag
Gln -27	-	expression tag
Phe -26	-	expression tag
Glu -25	-	expression tag
Lys -24	-	expression tag
Gly -23	-	expression tag
Gly -22	-	expression tag
Gly -21	-	expression tag
Gly -20	-	expression tag
Ser -19	-	expression tag
Gly -18	-	expression tag
Gly -17	-	expression tag
Ser -16	-	expression tag
Ala -15	-	expression tag
Trp -14	-	expression tag
Ser -13	-	expression tag
His -12	-	expression tag
Pro -11	-	expression tag
Gln -10	-	expression tag
Phe -9	-	expression tag
Glu -8	-	expression tag
Lys -7	-	expression tag
Glu -6	-	expression tag
Phe -5	-	expression tag
Lys -4	-	expression tag
Gly -3	-	expression tag
Leu -2	-	expression tag
Val -1	-	expression tag
Asp 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	134045.8
Non-Polymers*	Number of molecules	3
	Total formula weight	1177.7
All*	Total formula weight	135223.5

*Water molecules are not included.