9L88
Structure of human TREX1-DNA complex with K66R disease-associated mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, E, F (A, B, E, F) | Three-prime repair exonuclease 1 | polymer | 242 | 26008.9 | 4 | UniProt (Q9NSU2) | Homo sapiens (human) | 3'-5' exonuclease TREX1,Deoxyribonuclease III,DNase III |
| 2 | C, D, G, H (C, D, G, H) | DNA (5'-D(P*GP*TP*TP*GP*GP*CP*CP*CP*TP*CP*TP*TP*TP*AP*GP*GP*GP*CP*CP*AP*TP*C)-3') | polymer | 22 | 6710.3 | 4 | synthetic construct | ||
| 3 | I, J (B, F) | LITHIUM ION | non-polymer | 6.9 | 2 | Chemie (LI) PubChem (28486) | |||
| 4 | K, L, M, N, O... (A, B, C, D, E...) | water | water | 18.0 | 223 | Chemie (HOH) |
Sequence modifications
A, B, E, F: 1 - 242 (UniProt: Q9NSU2)
| PDB | External Database | Details |
|---|---|---|
| Arg 66 | Lys 66 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 130876.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 13.9 | |
| All* | Total formula weight | 130890.8 |
