Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

9L5R

Cryo-EM structure of the thermophile spliceosome (state ILS)

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(2)
U2 snRNApolymer19361393.81Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
2B
(5)
U5 snRNApolymer11636997.81Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
3C
(6)
U6 snRNApolymer10132443.31GenBank (170940748)Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
4D
(A)
PRP8polymer2463285131.01Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
5E
(B)
Pre-mRNA-splicing factor SYF2polymer32636945.91UniProt (G0S5N3)
Pfam (PF08231)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)SYF2
6F
(C)
SNU114polymer1011113867.61Pfam (PF16004)
Pfam (PF00009)
Pfam (PF03144)
Pfam (PF03764)
Pfam (PF00679)
UniProt (by SIFTS) (G0SBV2)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
7G
(D)
SDE2polymer32535780.91UniProt (G0RZD9)
Pfam (PF13019)
Pfam (PF22782)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)SDE2
8H
(E)
Anaphase-promoting complex subunit 4-like WD40 domain-containing proteinpolymer35238230.01UniProt (G0S9U7)
Pfam (PF00400)
Pfam (PF12894)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)U5-40K
9I
(F)
CCDC12polymer23325360.01UniProt (G0SDJ6)
Pfam (PF08315)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)CCDC12
10J
(I)
Putative pre-mRNA splicing proteinpolymer83997944.21UniProt (G0S620)
Pfam (PF23233)
Pfam (PF23220)
Pfam (PF23231)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)SYF1
11K
(J)
Suppressor of forked domain-containing proteinpolymer68782195.41UniProt (G0S0H7)
Pfam (PF23233)
Pfam (PF23240)
Pfam (PF23231)
Pfam (PF23241)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)SYF3
12L
(L)
Putative pre-mRNA splicing proteinpolymer76886636.21UniProt (G0S8A6)
Pfam (PF13921)
Pfam (PF11831)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)CDC5L
13M
(K)
Pre-mRNA-splicing factor SPF27polymer23125550.71UniProt (G0SDM8)
Pfam (PF05700)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)SPF27
14N, O, P, Q
(q, t, r, s)
Pre-mRNA-processing factor 19polymer48051844.34UniProt (G0SFY0)
Pfam (PF08606)
Pfam (PF00400)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)PRP19
15R
(N)
Putative bud site selection proteinpolymer14817176.81UniProt (G0S4Q2)
Pfam (PF01125)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)BUD31
16S
(S)
Peptidyl-prolyl cis-trans isomerasepolymer16718361.81UniProt (G0S1V3)
Pfam (PF00160)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)PPIL1,PPIase
17T
(T)
Pre-mRNA-splicing factor PRP46polymer49654207.31UniProt (G0S066)
Pfam (PF00400)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)PLRG1,Pre-mRNA-processing protein 46
18U
(U)
Cell cycle control proteinpolymer75788163.01UniProt (G0S730)
Pfam (PF04677)
Pfam (PF04676)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)CWF19L2
19V
(M)
Putative pre-mRNA splicing proteinpolymer39542241.81UniProt (G0RYD8)
Pfam (PF21369)
Pfam (PF00076)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)ECM2
20W
(0)
Putative pre-mRNA splicing proteinpolymer40845885.21UniProt (G0S7S7)
Pfam (PF16131)
Pfam (PF00076)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)CWC2
21X
(R)
Pre-mRNA-processing protein 45polymer57865194.51UniProt (G0SF87)
Pfam (PF02731)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)SKIP
22Y
(W)
PRP17polymer54761222.01UniProt (G0S2N1)
Pfam (PF00400)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)PRP17
23Z
(P)
Putative pre-mRNA splicing proteinpolymer26028956.61UniProt (G0S754)
Pfam (PF04889)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)CWC15
24AA
(Y)
Pre-mRNA-splicing factorpolymer1416161045.51UniProt (G0SFN9)
Pfam (PF16399)
Pfam (PF21143)
Pfam (PF21144)
Pfam (PF13086)
Pfam (PF13087)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)AQR
25BA, KA
(a, j)
Small nuclear ribonucleoprotein Epolymer9810967.82UniProt (G0S8J0)
Pfam (PF01423)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)smE,snRNP-E,Sm protein E
26CA, MA
(b, l)
Sm protein Fpolymer9410727.22UniProt (G0RY82)
Pfam (PF01423)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)smF
27DA, NA
(c, m)
Delta(14)-sterol reductasepolymer59266785.52UniProt (G0S405)
Pfam (PF01222)
Pfam (PF01423)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)smD2,C-14 sterol reductase,Sterol C14-reductase
28EA, OA
(d, o)
Small nuclear ribonucleoprotein Sm D1polymer11813033.12UniProt (G0RZL0)
Pfam (PF01423)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)smD1
29FA, PA
(e, p)
Sm protein Bpolymer21121425.52UniProt (G0SHQ3)
Pfam (PF01423)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)smB/B'
30GA, QA
(f, u)
Small nuclear ribonucleoprotein Sm D3polymer11412708.72UniProt (G0SG70)
Pfam (PF01423)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)smD3,Sm-D3,snRNP core protein D3
31HA, LA
(g, k)
Small nuclear ribonucleoprotein Gpolymer829259.82UniProt (G0SI53)
Pfam (PF01423)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)smG,snRNP-G
32IA
(h)
U2 small nuclear ribonucleoprotein A'polymer24227249.61UniProt (G0S6F0)
Pfam (PF14580)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)U2 snrnp A
33JA
(i)
U2 small nuclear ribonucleoprotein B'-like proteinpolymer20121744.81UniProt (G0SBL9)
Pfam (PF00076)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)U2 snrnp B
34RA
(CY)
Nineteen complex-related protein 2-domain-containing proteinpolymer51056472.41UniProt (G0SI54)
Pfam (PF15458)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)GCFC2
35SA
(Cb)
G-patch domain-containing proteinpolymer975110801.01UniProt (G0S394)
Pfam (PF12457)
Pfam (PF01585)
Pfam (PF07842)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)TFIP11
36TA
(Cc)
RNA helicasepolymer76487155.51UniProt (G0RY84)
Pfam (PF00270)
Pfam (PF00271)
Pfam (PF04408)
Pfam (PF21010)
Pfam (PF07717)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)DHX15
37UA
(7)
Unknown mRNApolymer10122185.01Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
38VA
(Ci)
Putative cyclophilin proteinpolymer15316600.31UniProt (G0RZE2)
Pfam (PF00076)
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)PPIE
39WA
(H)
Unknown proteinpolymer221890.31Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
40XA
(B)
N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate)non-polymer487.31Chemie (M7M)
41YA
(C)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
42ZA
(C)
GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
43AB
(J)
INOSITOL HEXAKISPHOSPHATEnon-polymer660.01Chemie (IHP)
44BB, CB, DB, EB, FB...
(N, U, M)
ZINC IONnon-polymer65.46Chemie (ZN)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains49
Total formula weight2382222.5
Non-Polymers*Number of molecules10
Total formula weight2087.3
All*Total formula weight2384309.8
*Water molecules are not included.

250359

PDB entries from 2026-03-11

PDB statisticsPDBj update infoContact PDBjnumon