9L3W
Cryo-EM structure of the chemokine-like receptor 1 in complex with chemerin and Gi1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40447.1 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (L) | Retinoic acid receptor responder protein 2 | polymer | 137 | 15904.2 | 1 | UniProt (Q99969) | Homo sapiens (human) | Chemerin,RAR-responsive protein TIG2,Tazarotene-induced gene 2 protein |
| 5 | E (R) | Chemerin-like receptor 1 | polymer | 419 | 47393.1 | 1 | UniProt (Q99788) Pfam (PF00001) | Homo sapiens (human) | Chemokine-like receptor 1,G-protein coupled receptor ChemR23,G-protein coupled receptor DEZ |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
R: 1 - 373 (UniProt: Q99788)
| PDB | External Database | Details |
|---|---|---|
| Cys 47 | Ser 47 | engineered mutation |
| Thr 202 | Gly 202 | engineered mutation |
| Ala 203 | Gly 203 | engineered mutation |
| Ala 245 | Glu 245 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Glu 374 | - | expression tag |
| Phe 375 | - | expression tag |
| Leu 376 | - | expression tag |
| Glu 377 | - | expression tag |
| Val 378 | - | expression tag |
| Leu 379 | - | expression tag |
| Phe 380 | - | expression tag |
| Gln 381 | - | expression tag |
| Gly 382 | - | expression tag |
| Pro 383 | - | expression tag |
| Trp 384 | - | expression tag |
| Ser 385 | - | expression tag |
| His 386 | - | expression tag |
| Pro 387 | - | expression tag |
| Gln 388 | - | expression tag |
| Phe 389 | - | expression tag |
| Glu 390 | - | expression tag |
| Lys 391 | - | expression tag |
| Gly 392 | - | expression tag |
| Gly 393 | - | expression tag |
| Gly 394 | - | expression tag |
| Ser 395 | - | expression tag |
| Gly 396 | - | expression tag |
| Gly 397 | - | expression tag |
| Gly 398 | - | expression tag |
| Ser 399 | - | expression tag |
| Gly 400 | - | expression tag |
| Gly 401 | - | expression tag |
| Ser 402 | - | expression tag |
| Ala 403 | - | expression tag |
| Trp 404 | - | expression tag |
| Ser 405 | - | expression tag |
| His 406 | - | expression tag |
| Pro 407 | - | expression tag |
| Gln 408 | - | expression tag |
| Phe 409 | - | expression tag |
| Glu 410 | - | expression tag |
| Lys 411 | - | expression tag |
| Asp 412 | - | expression tag |
| Tyr 413 | - | expression tag |
| Lys 414 | - | expression tag |
| Asp 415 | - | expression tag |
| Asp 416 | - | expression tag |
| Asp 417 | - | expression tag |
| Asp 418 | - | expression tag |
| Lys 419 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 149022.5 | |
| All* | Total formula weight | 149022.5 |
