9L3R

Human PI3KDELTA in complex with Zandelisib

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	polymer	1044	119633.0	1	UniProt (O00329) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454)	Homo sapiens (human)	PI3-kinase subunit delta,PI3K-delta,PI3Kdelta,PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,PtdIns-3-kinase subunit p110-delta,p110delta
2	B (B)	Phosphatidylinositol 3-kinase regulatory subunit alpha	polymer	172	21150.9	1	UniProt (P23727) Pfam (PF16454)	Bos taurus (domestic cattle)	PI3-kinase regulatory subunit alpha,PI3K regulatory subunit alpha,PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PI3-kinase subunit p85-alpha,PtdIns-3-kinase regulatory subunit p85-alpha
3	C (A)	Zandelisib	non-polymer		576.7	1	Chemie (A1L62) PubChem (66571003)
4	D, E (A, B)	water	water		18.0	49	Chemie (HOH)

Sequence modifications

B: 431 - 600 (UniProt: P23727)

PDB	External Database	Details
Ace 429	-	acetylation
Met 430	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	140783.9
Non-Polymers*	Number of molecules	1
	Total formula weight	576.7
All*	Total formula weight	141360.6

*Water molecules are not included.