9KZT

Cryo-EM structure of the 3:3 LGI1-ADAM22 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E (A, C, E)	Disintegrin and metalloproteinase domain-containing protein 22	polymer	497	54803.2	3	UniProt (Q9P0K1) Pfam (PF01421) Pfam (PF00200) Pfam (PF08516) Pfam (PF07974)	Homo sapiens (human)	ADAM 22,Metalloproteinase-disintegrin ADAM22-3,Metalloproteinase-like,disintegrin-like,and cysteine-rich protein 2
2	B, D, F (B, D, F)	Leucine-rich glioma-inactivated protein 1	polymer	544	62570.8	3	UniProt (O95970) Pfam (PF03736) Pfam (PF13855)	Homo sapiens (human)	Epitempin-1

Sequence modifications

B, D, F: 37 - 557 (UniProt: O95970)

PDB	External Database	Details
Asp 21	-	expression tag
Ala 22	-	expression tag
Ala 23	-	expression tag
Gln 24	-	expression tag
Pro 25	-	expression tag
Ala 26	-	expression tag
Arg 27	-	expression tag
Arg 28	-	expression tag
Ala 29	-	expression tag
Arg 30	-	expression tag
Arg 31	-	expression tag
Thr 32	-	expression tag
Tyr 33	-	expression tag
Glu 34	-	expression tag
Ala 35	-	expression tag
Tyr 36	-	expression tag
Ala 470	Arg 470	engineered mutation
Lys 558	-	expression tag
His 559	-	expression tag
His 560	-	expression tag
His 561	-	expression tag
His 562	-	expression tag
His 563	-	expression tag
His 564	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	352122.0
All*	Total formula weight	352122.0

*Water molecules are not included.