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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9KZT

Cryo-EM structure of the 3:3 LGI1-ADAM22 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
B0005102molecular_functionsignaling receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0007165biological_processsignal transduction
B0007399biological_processnervous system development
B0007411biological_processaxon guidance
B0030307biological_processpositive regulation of cell growth
B0030425cellular_componentdendrite
B0031175biological_processneuron projection development
B0043083cellular_componentsynaptic cleft
B0043194cellular_componentaxon initial segment
B0045202cellular_componentsynapse
B0048018molecular_functionreceptor ligand activity
B0050806biological_processpositive regulation of synaptic transmission
B0098978cellular_componentglutamatergic synapse
B0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
C0004222molecular_functionmetalloendopeptidase activity
C0006508biological_processproteolysis
C0008237molecular_functionmetallopeptidase activity
D0005102molecular_functionsignaling receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005794cellular_componentGolgi apparatus
D0007165biological_processsignal transduction
D0007399biological_processnervous system development
D0007411biological_processaxon guidance
D0030307biological_processpositive regulation of cell growth
D0030425cellular_componentdendrite
D0031175biological_processneuron projection development
D0043083cellular_componentsynaptic cleft
D0043194cellular_componentaxon initial segment
D0045202cellular_componentsynapse
D0048018molecular_functionreceptor ligand activity
D0050806biological_processpositive regulation of synaptic transmission
D0098978cellular_componentglutamatergic synapse
D0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
E0004222molecular_functionmetalloendopeptidase activity
E0006508biological_processproteolysis
E0008237molecular_functionmetallopeptidase activity
F0005102molecular_functionsignaling receptor binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005737cellular_componentcytoplasm
F0005783cellular_componentendoplasmic reticulum
F0005794cellular_componentGolgi apparatus
F0007165biological_processsignal transduction
F0007399biological_processnervous system development
F0007411biological_processaxon guidance
F0030307biological_processpositive regulation of cell growth
F0030425cellular_componentdendrite
F0031175biological_processneuron projection development
F0043083cellular_componentsynaptic cleft
F0043194cellular_componentaxon initial segment
F0045202cellular_componentsynapse
F0048018molecular_functionreceptor ligand activity
F0050806biological_processpositive regulation of synaptic transmission
F0098978cellular_componentglutamatergic synapse
F0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CvCnrHwiGSdC
ChainResidueDetails
ACYS700-CYS711
site_idPS00427
Number of Residues20
DetailsDISINTEGRIN_1 Disintegrins signature. CsdGlCCk.KCkFqpmgtvCR
ChainResidueDetails
ACYS485-ARG504
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues597
DetailsDomain: {"description":"Peptidase M12B","evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues261
DetailsDomain: {"description":"Disintegrin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00068","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues111
DetailsDomain: {"description":"EGF-like"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues9
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19692335","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues63
DetailsRepeat: {"description":"LRR 1"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues63
DetailsRepeat: {"description":"LRR 2"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues63
DetailsRepeat: {"description":"LRR 3"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues150
DetailsDomain: {"description":"LRRCT"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues126
DetailsRepeat: {"description":"EAR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00075","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues126
DetailsRepeat: {"description":"EAR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00075","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues141
DetailsRepeat: {"description":"EAR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00075","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues147
DetailsRepeat: {"description":"EAR 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00075","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues129
DetailsRepeat: {"description":"EAR 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00075","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues126
DetailsRepeat: {"description":"EAR 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00075","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues9
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2026-01-21

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