9KZ4
Dihydrofolate reductase binding to NADPH and trimethoprim-tetramethylrhodamine
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Dihydrofolate reductase | polymer | 159 | 17986.2 | 2 | UniProt (P0ABQ4) Pfam (PF00186) | Escherichia coli K-12 | |
| 2 | C, H (B, A) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 3 | D, I (B, A) | [9-[5-[2-[4-[[2,4-bis(azanyl)pyrimidin-5-yl]methyl]-2,6-dimethoxy-phenoxy]ethylcarbamoyl]-2-carboxy-phenyl]-6-(dimethylamino)xanthen-3-ylidene]-dimethyl-azanium | non-polymer | 732.8 | 2 | Chemie (A1EHX) PubChem (172643408) | |||
| 4 | E, F, G, J, K... (B, A) | MAGNESIUM ION | non-polymer | 24.3 | 7 | Chemie (MG) PubChem (888) | |||
| 5 | N, O (B, A) | water | water | 18.0 | 237 | Chemie (HOH) |
Sequence modifications
B, A: 2 - 159 (UniProt: P0ABQ4)
| PDB | External Database | Details |
|---|---|---|
| Pro 1 | - | expression tag |
| Asp 37 | Asn 37 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35972.5 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 3126.6 | |
| All* | Total formula weight | 39099.1 |
