9KTK
Crystal structure of human SIRT3 with its activator SKLB-11A
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | polymer | 277 | 30799.4 | 4 | UniProt (Q9NTG7) Pfam (PF02146) | Homo sapiens (human) | hSIRT3,NAD-dependent protein delactylase sirtuin-3,Regulatory protein SIR2 homolog 3,SIR2-like protein 3 |
| 2 | E, G, J, M (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, I, L, O (A, B, C, D) | methyl 2-azanyl-1-[(4-fluorophenyl)methyl]pyrrolo[3,2-b]quinoxaline-3-carboxylate | non-polymer | 350.3 | 4 | Chemie (A1EHU) | |||
| 4 | H, K, N (B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) |
Sequence modifications
A, B, C, D: 118 - 391 (UniProt: Q9NTG7)
| PDB | External Database | Details |
|---|---|---|
| Ser 115 | - | expression tag |
| Asn 116 | - | expression tag |
| Ala 117 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 123197.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1735.9 | |
| All* | Total formula weight | 124933.7 |
