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9KOH

Structure of human PRC2-SAH-H3K27me3-C36

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(I)
Histone-lysine N-methyltransferase EZH2polymer75486597.51UniProt (Q15910)Homo sapiens (human)ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6
2B, D
(C, E)
H3K27me3polymer101045.32Homo sapiens
3C
(D)
Polycomb protein EEDpolymer36241808.51UniProt (O75530)Homo sapiens (human)hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1
4E
(O)
Polycomb protein SUZ12polymer59769661.21UniProt (Q15022)Homo sapiens (human)Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog
5F
(F)
Zinc finger protein AEBP2polymer10612236.21UniProt (Q6ZN18)Homo sapiens (human)Adipocyte enhancer-binding protein 2,AE-binding protein 2
6G
(K)
RB binding protein 4, chromatin remodeling factor,Histone-binding protein RBBP4polymer49255730.81UniProt (E9PNS6)
UniProt (Q09028)
Homo sapiens (human)Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I 48 kDa subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48
7H
(I)
2-[2-[[4-[(8-chloranyl-1,7-naphthyridin-2-yl)amino]cyclohexyl]methylamino]pyrimidin-5-yl]-N-(oxetan-3-yl)ethanamidenon-polymer482.01Chemie (A1EGC)
8I
(I)
S-ADENOSYL-L-HOMOCYSTEINEnon-polymer384.41Chemie (SAH)
PubChem (439155)
Sequence modifications
I: 1 - 746 (UniProt: Q15910)
PDBExternal DatabaseDetails
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
His -2-expression tag
His -1-expression tag
His 0-expression tag
K: -81 - 3 (UniProt: E9PNS6)
K: 4 - 495 (UniProt: Q09028)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains7
Total formula weight268124.7
Non-Polymers*Number of molecules2
Total formula weight866.4
All*Total formula weight268991.1
*Water molecules are not included.

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PDB entries from 2026-06-17

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