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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9KOH

Structure of human PRC2-SAH-H3K27me3-C36

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
I0000122biological_processnegative regulation of transcription by RNA polymerase II
I0000781cellular_componentchromosome, telomeric region
I0000785cellular_componentchromatin
I0000792cellular_componentheterochromatin
I0000976molecular_functiontranscription cis-regulatory region binding
I0001222molecular_functiontranscription corepressor binding
I0003682molecular_functionchromatin binding
I0003714molecular_functiontranscription corepressor activity
I0003723molecular_functionRNA binding
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005694cellular_componentchromosome
I0006325biological_processchromatin organization
I0006355biological_processregulation of DNA-templated transcription
I0008284biological_processpositive regulation of cell population proliferation
I0010629biological_processnegative regulation of gene expression
I0010718biological_processpositive regulation of epithelial to mesenchymal transition
I0016279molecular_functionprotein-lysine N-methyltransferase activity
I0021766biological_processhippocampus development
I0030335biological_processpositive regulation of cell migration
I0031048biological_processregulatory ncRNA-mediated heterochromatin formation
I0031490molecular_functionchromatin DNA binding
I0031491molecular_functionnucleosome binding
I0031507biological_processheterochromatin formation
I0031509biological_processsubtelomeric heterochromatin formation
I0032355biological_processresponse to estradiol
I0035098cellular_componentESC/E(Z) complex
I0042054molecular_functionhistone methyltransferase activity
I0042393molecular_functionhistone binding
I0042752biological_processregulation of circadian rhythm
I0043406biological_processpositive regulation of MAP kinase activity
I0043547biological_processpositive regulation of GTPase activity
I0045202cellular_componentsynapse
I0045814biological_processnegative regulation of gene expression, epigenetic
I0045892biological_processnegative regulation of DNA-templated transcription
I0046976molecular_functionhistone H3K27 methyltransferase activity
I0048387biological_processnegative regulation of retinoic acid receptor signaling pathway
I0051932biological_processsynaptic transmission, GABAergic
I0071902biological_processpositive regulation of protein serine/threonine kinase activity
I0090183biological_processregulation of kidney development
I0140718biological_processfacultative heterochromatin formation
I0140938molecular_functionhistone H3 methyltransferase activity
I0140951molecular_functionhistone H3K27 trimethyltransferase activity
I1900006biological_processpositive regulation of dendrite development
I1900016biological_processnegative regulation of cytokine production involved in inflammatory response
I1902808biological_processpositive regulation of cell cycle G1/S phase transition
I1990841molecular_functionpromoter-specific chromatin binding
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues22
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cpw..CtlnCrklysllkHlklc.H
ChainResidueDetails
OCYS450-HIS471
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTICLWDI
ChainResidueDetails
KLEU278-ILE292
KLEU374-LEU388
KLEU418-LEU432
DLEU206-ILE220
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues115
DetailsDomain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues29
DetailsRegion: {"description":"Interaction with EED","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues43
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues43
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues40
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues41
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues37
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues40
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues33
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues360
DetailsRegion: {"description":"Interaction with EZH2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues294
DetailsRegion: {"description":"Required for interaction with the matrix protein MA of HIV-1"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues3
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues23
DetailsZinc finger: {"description":"C2H2-type"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues76
DetailsRegion: {"description":"VEFS-box"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsSite: {"description":"Breakpoint for translocation to form JAZF1-SUZ12 oncogene"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues71
DetailsRegion: {"description":"Interaction with SUZ12","evidences":[{"source":"PubMed","id":"29499137","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues49
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues47
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues45
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues43
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues56
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues32
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q60972","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

257629

PDB entries from 2026-08-05

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