9KOG

Structure of human PRC2 with C36 compound

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone-lysine N-methyltransferase EZH2	polymer	754	86615.5	1	UniProt (Q15910)	Homo sapiens (human)	ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6
2	B (D)	Polycomb protein EED	polymer	448	51199.7	1	UniProt (O75530)	Homo sapiens (human)	hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1
3	C (C)	Polycomb protein SUZ12	polymer	600	70049.7	1	UniProt (Q15022)	Homo sapiens (human)	Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog
4	D (F)	Zinc finger protein AEBP2	polymer	106	12236.2	1	UniProt (Q6ZN18)	Homo sapiens (human)	Adipocyte enhancer-binding protein 2,AE-binding protein 2
5	E (H)	Histone-binding protein RBBP4	polymer	407	45892.8	1	UniProt (Q09028)	Homo sapiens (human)	Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I 48 kDa subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48
6	F (A)	2-[2-[[4-[(8-chloranyl-1,7-naphthyridin-2-yl)amino]cyclohexyl]methylamino]pyrimidin-5-yl]-N-(oxetan-3-yl)ethanamide	non-polymer		482.0	1	Chemie (A1EGC)

Sequence modifications

A: 1 - 746 (UniProt: Q15910)

PDB	External Database	Details
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Asp 258	Pro 258	conflict

D: 1 - 439 (UniProt: O75530)

PDB	External Database	Details
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Leu 81	Ser 81	conflict
Ala 440	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	265993.7
Non-Polymers*	Number of molecules	1
	Total formula weight	482.0
All*	Total formula weight	266475.7

*Water molecules are not included.