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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9KOG

Structure of human PRC2 with C36 compound

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0000792cellular_componentheterochromatin
A0000976molecular_functiontranscription cis-regulatory region binding
A0001222molecular_functiontranscription corepressor binding
A0003682molecular_functionchromatin binding
A0003714molecular_functiontranscription corepressor activity
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0006325biological_processchromatin organization
A0006355biological_processregulation of DNA-templated transcription
A0008284biological_processpositive regulation of cell population proliferation
A0010629biological_processnegative regulation of gene expression
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0016279molecular_functionprotein-lysine N-methyltransferase activity
A0021766biological_processhippocampus development
A0030335biological_processpositive regulation of cell migration
A0031048biological_processregulatory ncRNA-mediated heterochromatin formation
A0031490molecular_functionchromatin DNA binding
A0031491molecular_functionnucleosome binding
A0031507biological_processheterochromatin formation
A0031509biological_processsubtelomeric heterochromatin formation
A0032355biological_processresponse to estradiol
A0035098cellular_componentESC/E(Z) complex
A0042054molecular_functionhistone methyltransferase activity
A0042393molecular_functionhistone binding
A0042752biological_processregulation of circadian rhythm
A0043406biological_processpositive regulation of MAP kinase activity
A0043547biological_processpositive regulation of GTPase activity
A0045202cellular_componentsynapse
A0045814biological_processnegative regulation of gene expression, epigenetic
A0045892biological_processnegative regulation of DNA-templated transcription
A0046976molecular_functionhistone H3K27 methyltransferase activity
A0048387biological_processnegative regulation of retinoic acid receptor signaling pathway
A0051932biological_processsynaptic transmission, GABAergic
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0090183biological_processregulation of kidney development
A0140718biological_processfacultative heterochromatin formation
A0140938molecular_functionhistone H3 methyltransferase activity
A0140951molecular_functionhistone H3K27 trimethyltransferase activity
A1900006biological_processpositive regulation of dendrite development
A1900016biological_processnegative regulation of cytokine production involved in inflammatory response
A1902808biological_processpositive regulation of cell cycle G1/S phase transition
A1990841molecular_functionpromoter-specific chromatin binding
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001222molecular_functiontranscription corepressor binding
D0003682molecular_functionchromatin binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0008047molecular_functionenzyme activator activity
D0021510biological_processspinal cord development
D0031491molecular_functionnucleosome binding
D0031507biological_processheterochromatin formation
D0035098cellular_componentESC/E(Z) complex
D0042802molecular_functionidentical protein binding
D0045892biological_processnegative regulation of DNA-templated transcription
D0140718biological_processfacultative heterochromatin formation
H0000118cellular_componenthistone deacetylase complex
H0000122biological_processnegative regulation of transcription by RNA polymerase II
H0000781cellular_componentchromosome, telomeric region
H0000785cellular_componentchromatin
H0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0006335biological_processDNA replication-dependent chromatin assembly
H0006338biological_processchromatin remodeling
H0006355biological_processregulation of DNA-templated transcription
H0007420biological_processbrain development
H0008094molecular_functionATP-dependent activity, acting on DNA
H0008285biological_processnegative regulation of cell population proliferation
H0016581cellular_componentNuRD complex
H0016589cellular_componentNURF complex
H0030336biological_processnegative regulation of cell migration
H0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
H0031492molecular_functionnucleosomal DNA binding
H0031507biological_processheterochromatin formation
H0032991cellular_componentprotein-containing complex
H0033186cellular_componentCAF-1 complex
H0035098cellular_componentESC/E(Z) complex
H0042393molecular_functionhistone binding
H0042659biological_processregulation of cell fate specification
H0042826molecular_functionhistone deacetylase binding
H0045892biological_processnegative regulation of DNA-templated transcription
H0045893biological_processpositive regulation of DNA-templated transcription
H0045944biological_processpositive regulation of transcription by RNA polymerase II
H0070176cellular_componentDRM complex
H0070822cellular_componentSin3-type complex
H0090575cellular_componentRNA polymerase II transcription regulator complex
H1902455biological_processnegative regulation of stem cell population maintenance
H1902459biological_processpositive regulation of stem cell population maintenance
H1904949cellular_componentATPase complex
H2000736biological_processregulation of stem cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues22
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cpw..CtlnCrklysllkHlklc.H
ChainResidueDetails
CCYS450-HIS471
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI
ChainResidueDetails
DLEU206-ILE220
HLEU167-ILE181
HLEU263-LEU277
HLEU307-LEU321
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues115
DetailsDomain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues29
DetailsRegion: {"description":"Interaction with EED","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PKB/AKT1","evidences":[{"source":"PubMed","id":"16224021","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsGlycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"PubMed","id":"24474760","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues43
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues43
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues40
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues41
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues37
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues40
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues154
DetailsRegion: {"description":"Required for interaction with the matrix protein MA of HIV-1"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues3
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues23
DetailsZinc finger: {"description":"C2H2-type"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues76
DetailsRegion: {"description":"VEFS-box"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsSite: {"description":"Breakpoint for translocation to form JAZF1-SUZ12 oncogene"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues71
DetailsRegion: {"description":"Interaction with SUZ12","evidences":[{"source":"PubMed","id":"29499137","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues49
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues47
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues45
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues43
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues56
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues32
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q60972","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

257629

PDB entries from 2026-08-05

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