9KHH

Structure of the complex of LGR4 with Norrin (2:2)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, B)	MB52	polymer	556	59266.4	2		Camelus dromedarius
2	B, C (E, F)	Norrin,Immunoglobulin gamma-1 heavy chain	polymer	409	45313.4	2	UniProt (Q00604) UniProt (P0DOX5) Pfam (PF07654) Pfam (PF00007)	Homo sapiens (human)	Norrie disease protein,X-linked exudative vitreoretinopathy 2 protein,Immunoglobulin gamma-1 heavy chain NIE
3	E, F (C, D)	Leucine-rich repeat-containing G-protein coupled receptor 4	polymer	954	105397.5	2	UniProt (Q9BXB1) Pfam (PF01462) Pfam (PF13855) Pfam (PF00001)	Homo sapiens (human)	G-protein coupled receptor 48

Sequence modifications

E, F: 25 - 133 (UniProt: Q00604)

PDB	External Database	Details
Met -13	-	initiating methionine
Leu -12	-	expression tag
Leu -11	-	expression tag
Val -10	-	expression tag
Asn -9	-	expression tag
Gln -8	-	expression tag
Ser -7	-	expression tag
His -6	-	expression tag
Gln -5	-	expression tag
Gly -4	-	expression tag
Phe -3	-	expression tag
Asn -2	-	expression tag
Lys -1	-	expression tag
Glu 0	-	expression tag
His 1	-	expression tag
Thr 2	-	expression tag
Ser 3	-	expression tag
Lys 4	-	expression tag
Met 5	-	expression tag
Val 6	-	expression tag
Ser 7	-	expression tag
Ala 8	-	expression tag
Ile 9	-	expression tag
Val 10	-	expression tag
Leu 11	-	expression tag
Tyr 12	-	expression tag
Val 13	-	expression tag
Leu 14	-	expression tag
Leu 15	-	expression tag
Ala 16	-	expression tag
Ala 17	-	expression tag
Ala 18	-	expression tag
Ala 19	-	expression tag
His 20	-	expression tag
Ser 21	-	expression tag
Ala 22	-	expression tag
Phe 23	-	expression tag
Ala 24	-	expression tag
Gly 134	-	linker
Gly 135	-	linker
Ser 136	-	linker
Gly 137	-	linker
Gly 138	-	linker
Ser 139	-	linker
Gly 140	-	linker
Gly 141	-	linker
Leu 142	-	linker
Glu 143	-	linker
Val 144	-	linker
Leu 145	-	linker
Phe 146	-	linker
Gln 147	-	linker
Gly 148	-	linker
Pro 149	-	linker
Gly 150	-	linker
Gly 151	-	linker
Ser 152	-	linker
Gly 153	-	linker
Gly 154	-	linker
Ser 155	-	linker
Gly 156	-	linker
Gly 157	-	linker

E, F: 158 - 387 (UniProt: P0DOX5)

PDB	External Database	Details
Ala 333	Thr 395	conflict
Asp 388	-	expression tag
Tyr 389	-	expression tag
Lys 390	-	expression tag
Asp 391	-	expression tag
Asp 392	-	expression tag
Asp 393	-	expression tag
Asp 394	-	expression tag
Lys 395	-	expression tag

C, D: 24 - 951 (UniProt: Q9BXB1)

PDB	External Database	Details
Met 9	-	initiating methionine
Lys 10	-	expression tag
Thr 11	-	expression tag
Ile 12	-	expression tag
Ile 13	-	expression tag
Ala 14	-	expression tag
Leu 15	-	expression tag
Ser 16	-	expression tag
Tyr 17	-	expression tag
Ile 18	-	expression tag
Phe 19	-	expression tag
Cys 20	-	expression tag
Leu 21	-	expression tag
Val 22	-	expression tag
Phe 23	-	expression tag
Ala 952	-	expression tag
Ala 953	-	expression tag
Ala 954	-	expression tag
Asp 955	-	expression tag
Tyr 956	-	expression tag
Lys 957	-	expression tag
Asp 958	-	expression tag
Asp 959	-	expression tag
Asp 960	-	expression tag
Asp 961	-	expression tag
Lys 962	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	419954.6
All*	Total formula weight	419954.6

*Water molecules are not included.