Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9KHH

Structure of the complex of LGR4 with Norrin (2:2)

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0000278	biological_process	mitotic cell cycle
E	0000320	biological_process	re-entry into mitotic cell cycle
E	0001508	biological_process	action potential
E	0001525	biological_process	angiogenesis
E	0001666	biological_process	response to hypoxia
E	0001890	biological_process	placenta development
E	0001974	biological_process	blood vessel remodeling
E	0002088	biological_process	lens development in camera-type eye
E	0003406	biological_process	retinal pigment epithelium development
E	0003407	biological_process	neural retina development
E	0005109	molecular_function	frizzled binding
E	0005125	molecular_function	cytokine activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006099	biological_process	tricarboxylic acid cycle
E	0006366	biological_process	transcription by RNA polymerase II
E	0006544	biological_process	glycine metabolic process
E	0006563	biological_process	L-serine metabolic process
E	0006622	biological_process	protein targeting to lysosome
E	0006749	biological_process	glutathione metabolic process
E	0006954	biological_process	inflammatory response
E	0007033	biological_process	vacuole organization
E	0007179	biological_process	transforming growth factor beta receptor signaling pathway
E	0007224	biological_process	smoothened signaling pathway
E	0007399	biological_process	nervous system development
E	0007601	biological_process	visual perception
E	0008104	biological_process	intracellular protein localization
E	0008283	biological_process	cell population proliferation
E	0009986	cellular_component	cell surface
E	0010467	biological_process	gene expression
E	0010842	biological_process	retina layer formation
E	0014004	biological_process	microglia differentiation
E	0016055	biological_process	Wnt signaling pathway
E	0016358	biological_process	dendrite development
E	0016567	biological_process	protein ubiquitination
E	0021554	biological_process	optic nerve development
E	0030182	biological_process	neuron differentiation
E	0031290	biological_process	retinal ganglion cell axon guidance
E	0035426	biological_process	extracellular matrix-cell signaling
E	0035640	biological_process	exploration behavior
E	0042803	molecular_function	protein homodimerization activity
E	0045446	biological_process	endothelial cell differentiation
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046697	biological_process	decidualization
E	0048678	biological_process	response to axon injury
E	0051402	biological_process	neuron apoptotic process
E	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
E	0060041	biological_process	retina development in camera-type eye
E	0060042	biological_process	retina morphogenesis in camera-type eye
E	0060070	biological_process	canonical Wnt signaling pathway
E	0060221	biological_process	retinal rod cell differentiation
E	0060856	biological_process	establishment of blood-brain barrier
E	0060996	biological_process	dendritic spine development
E	0061298	biological_process	retina vasculature development in camera-type eye
E	0061299	biological_process	retina vasculature morphogenesis in camera-type eye
E	0061304	biological_process	retinal blood vessel morphogenesis
E	0061518	biological_process	microglial cell proliferation
E	0070086	biological_process	ubiquitin-dependent endocytosis
E	0071456	biological_process	cellular response to hypoxia
E	0097601	biological_process	retina blood vessel maintenance
E	0110135	biological_process	Norrin signaling pathway
E	1904390	biological_process	cone retinal bipolar cell differentiation
E	1990963	biological_process	establishment of blood-retinal barrier
F	0000278	biological_process	mitotic cell cycle
F	0000320	biological_process	re-entry into mitotic cell cycle
F	0001508	biological_process	action potential
F	0001525	biological_process	angiogenesis
F	0001666	biological_process	response to hypoxia
F	0001890	biological_process	placenta development
F	0001974	biological_process	blood vessel remodeling
F	0002088	biological_process	lens development in camera-type eye
F	0003406	biological_process	retinal pigment epithelium development
F	0003407	biological_process	neural retina development
F	0005109	molecular_function	frizzled binding
F	0005125	molecular_function	cytokine activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006099	biological_process	tricarboxylic acid cycle
F	0006366	biological_process	transcription by RNA polymerase II
F	0006544	biological_process	glycine metabolic process
F	0006563	biological_process	L-serine metabolic process
F	0006622	biological_process	protein targeting to lysosome
F	0006749	biological_process	glutathione metabolic process
F	0006954	biological_process	inflammatory response
F	0007033	biological_process	vacuole organization
F	0007179	biological_process	transforming growth factor beta receptor signaling pathway
F	0007224	biological_process	smoothened signaling pathway
F	0007399	biological_process	nervous system development
F	0007601	biological_process	visual perception
F	0008104	biological_process	intracellular protein localization
F	0008283	biological_process	cell population proliferation
F	0009986	cellular_component	cell surface
F	0010467	biological_process	gene expression
F	0010842	biological_process	retina layer formation
F	0014004	biological_process	microglia differentiation
F	0016055	biological_process	Wnt signaling pathway
F	0016358	biological_process	dendrite development
F	0016567	biological_process	protein ubiquitination
F	0021554	biological_process	optic nerve development
F	0030182	biological_process	neuron differentiation
F	0031290	biological_process	retinal ganglion cell axon guidance
F	0035426	biological_process	extracellular matrix-cell signaling
F	0035640	biological_process	exploration behavior
F	0042803	molecular_function	protein homodimerization activity
F	0045446	biological_process	endothelial cell differentiation
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0046697	biological_process	decidualization
F	0048678	biological_process	response to axon injury
F	0051402	biological_process	neuron apoptotic process
F	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F	0060041	biological_process	retina development in camera-type eye
F	0060042	biological_process	retina morphogenesis in camera-type eye
F	0060070	biological_process	canonical Wnt signaling pathway
F	0060221	biological_process	retinal rod cell differentiation
F	0060856	biological_process	establishment of blood-brain barrier
F	0060996	biological_process	dendritic spine development
F	0061298	biological_process	retina vasculature development in camera-type eye
F	0061299	biological_process	retina vasculature morphogenesis in camera-type eye
F	0061304	biological_process	retinal blood vessel morphogenesis
F	0061518	biological_process	microglial cell proliferation
F	0070086	biological_process	ubiquitin-dependent endocytosis
F	0071456	biological_process	cellular response to hypoxia
F	0097601	biological_process	retina blood vessel maintenance
F	0110135	biological_process	Norrin signaling pathway
F	1904390	biological_process	cone retinal bipolar cell differentiation
F	1990963	biological_process	establishment of blood-retinal barrier

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	22
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cdc..CesfLltkpvsckHliks.H

Chain	Residue	Details
C	CYS858-HIS879

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FSCSVMH

Chain	Residue	Details
E	PHE363-HIS369

site_id	PS01185
Number of Residues	37
Details	CTCK_1 C-terminal cystine knot signature. CCrpqtsklkalrlrCsgGmrltatyryilsChCee..C

Chain	Residue	Details
E	CYS95-CYS131

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	93
Details	Domain: {"description":"CTCK","evidences":[{"source":"PROSITE-ProRule","id":"PRU00039","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	18
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	96
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

Details

site_id	SWS_FT_FI10
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	42
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	42
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	42
Details	Repeat: {"description":"LRR 3"}

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Residue

Details

site_id	SWS_FT_FI14
Number of Residues	42
Details	Repeat: {"description":"LRR 4"}

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Residue

Details

site_id	SWS_FT_FI15
Number of Residues	46
Details	Repeat: {"description":"LRR 5"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	42
Details	Repeat: {"description":"LRR 6"}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	42
Details	Repeat: {"description":"LRR 7"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	42
Details	Repeat: {"description":"LRR 8"}

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Residue

Details

site_id	SWS_FT_FI19
Number of Residues	42
Details	Repeat: {"description":"LRR 9"}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	42
Details	Repeat: {"description":"LRR 10"}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	42
Details	Repeat: {"description":"LRR 11"}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	42
Details	Repeat: {"description":"LRR 12"}

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Residue

Details

site_id	SWS_FT_FI23
Number of Residues	42
Details	Repeat: {"description":"LRR 13"}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	42
Details	Repeat: {"description":"LRR 14"}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	42
Details	Repeat: {"description":"LRR 15"}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23756652","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)